Amino acid imbalance in patients with chronic liver diseases
Amino acid imbalance in patients with chronic liver diseases
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DOI：
10.1111/j.1872-034x.2009.00614.x
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发表时间：
2010-04-01
影响因子：
4.2
通讯作者：
Onji, Morikazu
中科院分区：
文献类型：
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作者：
Michitaka, Kojiro;Hiraoka, Atsushi;Onji, Morikazu
目的：本研究的目的是阐明慢性肝炎 (CH) 和肝硬化 (LC) 患者的氨基酸失衡。方法：我们测定了 101 名 CH 患者（37 名纤维化 F1 期、23 名 F2 期、21 名 F3 期）和 20 名 LC 患者血清中的总支链氨基酸 (BCAA)、酪氨酸 (Tyr) 水平及其比率 (BTR) (F4)经肝活检确诊者。分析其水平与肝纤维化分期的关系。结果：BTR低于正常范围的患者比例，CH患者为32.1%，LC患者为75.0%。与 CH 患者相比，LC 患者 BTR 和 BCAA 水平显着降低（分别为 P < 0.001、P < 0.05），Tyr 水平显着升高（P < 0.001）。 BTR 水平根据分期而下降。 F4中Tyr水平升高，而BCAA水平显着下降（F1为487+/-103，F2为483+/-122，F3为487+/-111，F4为423+/-94）。结论：相当数量的LC患者和CH患者的BTR水平较低。研究表明，Tyr的氨基酸失衡出现在肝病早期，而BCAA的减少主要出现在F4期。
Aim:The aim of this study is to clarify the amino acid imbalance in patients with chronic hepatitis (CH) as well as those with liver cirrhosis (LC).Methods:We assayed total branched-chain amino acids (BCAA), tyrosine (Tyr) levels and their ratio (BTR) in sera of 101 patients with CH (37 in fibrosis stage F1, 23 in F2, 21 in F3) and 20 with LC (F4) who were diagnosed by liver biopsy. Their levels in relation to the staging of liver fibrosis were analyzed.Results:The percentage of patients whose BTR was less than the normal range was 32.1% in CH and 75.0% in LC. The levels of BTR and BCAA were significantly lower (P < 0.001, P < 0.05, respectively) and that of Tyr was significantly higher (P < 0.001) in patients with LC than those in CH. The levels of BTR decreased according to the staging. The levels of Tyr increased according the staging, whereas the levels of BCAA deceased prominently in F4 (487 +/- 103 in F1, 483 +/- 122 in F2, 487 +/- 111 in F3 and 423 +/- 94 in F4).Conclusion:A considerable number of patients not only with LC but also with CH showed lower levels of BTR. It has been clarified that amino acid imbalance of Tyr was found in the early stage of liver disease, whereas decrease of BCAA was found mainly in F4 stage.