Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: computed tomography is useful for evaluation.
Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: computed tomography is useful for evaluation.
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DOI：
10.1007/s00535-015-1068-x
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发表时间：
2015-12
影响因子：
6.3
通讯作者：
Michitaka K
中科院分区：
文献类型：
--
作者：
Hiraoka A;Aibiki T;Okudaira T;Toshimori A;Kawamura T;Nakahara H;Suga Y;Azemoto N;Miyata H;Miyamoto Y;Ninomiya T;Hirooka M;Abe M;Matsuura B;Hiasa Y;Michitaka K
肌肉萎缩的定义及其诊断标准尚未得到充分报道，以阐明慢性肝病（CLD）的骨骼前骨骼频率（CLD）。 ）调查结果。
我们招募了988个CLD（736个具有幼稚的肝细胞癌）和372名正常对照受试者（NC）。使用个人计算机软件进行计算。 45.6±5.7岁（n = 61），女性47.0±6.1岁（n = 49），老年人被定义为65岁或以上。
在CLD组（HCV：HBV：HBV和HCV：酒精：非HBV和HCV = 652：88：7：82：159）中，在15.3％的慢性肝炎患者中观察到 - 骨肉phe（CH），24.4.44.4.4.44.44.44.44.44.44.44.44.44.44.44.44 expav。患有肝肝硬化（LC）儿童PUGH A的患者中，有37.7％的LC儿童PUGH B，其中37.1％的LC Child-PughC。 55–64，65–74，≥75岁）表明，CH前占骨pre的频率都高于CH的频率（1.8 vs. 3.6％，3.2，3.2 vs. 15.9％，4.9，4.9 vs. 13.4％，14.3 vs. 20.2 vs. 20.2 vs. 20.2 ％的PI值。 。
在CT发现和运动指导方面，应在早期阶段，甚至非细胞的CLD以及LC进行回顾性评估。
The definition of muscle atrophy (pre-sarcopenia) and its diagnostic criteria have not been well reported. To elucidate the frequency of pre-sarcopenia in chronic liver disease (CLD), we examined clinical features of Japanese CLD patients using abdominal computed tomography (CT) findings. We enrolled 988 CLD (736 with naïve hepatocellular carcinoma) and 372 normal control subjects (NCs). The psoas muscle area index [PI, psoas muscle area at the mid-L3 level in CT (cm2)/height (m)2] was calculated using personal computer software. The cut-off level for pre-sarcopenia was defined as less than two standard deviations (SDs) below the mean PI value in the NCs under 55 years old [males, 45.6 ± 5.7 years (n = 61), 4.24 cm2/m2; females, 47.0 ± 6.1 years (n = 49), 2.50 cm2/m2]. Elderly was defined as 65 years or older. Clinical features were retrospectively evaluated. In the CLD group (HCV:HBV:HBV and HCV:alcohol:non-HBV and HCV = 652:88:7:82:159), pre-sarcopenia was observed in 15.3 % of patients with chronic hepatitis (CH), 24.4 % of those with liver cirrhosis (LC) Child-Pugh A, 37.7 % of those with LC Child-Pugh B, and 37.1 % of those with LC Child-Pugh C. A comparison between NC and CH by age (<55, 55–64, 65–74, ≥75 years) showed that the frequency of pre-sarcopenia was higher in CH regardless of age (1.8 vs. 3.6 %, 3.2 vs. 15.9 %, 4.9 vs. 13.4 %, 14.3 vs. 20.2 %, respectively). PI values showed correlations with BMI (r = 0.361), age (r = −0.167), albumin (r = 0.115), and branched-chain amino acids (r = 0.199) (P < 0.01). Retrospective evaluate for pre-sarcopenia was easy to perform with CT findings. Nutrition and exercise instruction should be considered for early stage and even non-elderly CLD as well as LC.