White matter integrity in older females is altered by increased body fat.
White matter integrity in older females is altered by increased body fat.
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DOI：
10.1002/oby.20815
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Walther K
中科院分区：
文献类型：
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作者：
Ryan L;Walther K
评估显示白色物质体积BMI相关增加的个体队列中的扩散变化模式是否反映了髓鞘的健康扩张或受损的白色物质。从94名年龄在52-92岁的女性中获得弥散MRI测量（轴向、径向和各向异性分数）。BMI和扩散测量之间的关系进行了评估，控制年龄，高血压和糖尿病状态使用一般线性模型。扩散测量和认知状态（记忆，执行功能和视觉速度）之间的关联进行了评估，使用多元回归，控制年龄，教育，高血压和糖尿病状态。BMI水平越高，额叶、颞叶、顶叶、内囊和小脑白色物质的轴向弥散越低。双侧颞叶白色物质和右侧皮质脊髓束的各向异性分数较低，颞叶和颞顶白色物质的放射状扩散较高。重要的是，扩散措施预测执行功能，记忆和视觉速度的下降。显示BMI相关体积增加的白色物质区域的扩散变化模式不是由于正常髓鞘的扩张，而是表明对认知功能具有重要影响的白色物质的损伤。
To assess whether the pattern of diffusion changes among a cohort of individuals showing BMI-related increases in white matter volume reflects healthy expansion of myelin or damaged white matter. Diffusion MRI measures (axial, radial, and fractional anisotropy) were obtained from 94 females, ages 52–92. Relationships between BMI and diffusion measures were assessed controlling for age, hypertension, and diabetes status using general linear modelling. Associations between diffusion measures and cognitive status (memory, executive functions, and visuomotor speed) were assessed using multiple regressions, controlling for age, education, hypertension, and diabetes status. Higher levels of BMI were associated with lower axial diffusion in frontal, temporal, parietal, internal capsule, and cerebellar white matter. Lower fractional anisotropy was observed in bilateral temporal white matter and the right corticospinal tract, with high radial diffusion in temporal and temporoparietal white matter. Importantly, diffusion measures predicted reductions in executive functioning, memory, and visuomotor speed. The pattern of diffusion changes in regions of white matter showing BMI-related volume increases are not due to expansion of normal myelin, but instead suggest damage to white matter that has important consequences for cognitive functioning.