MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation.
MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation.
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DOI：
10.5483/bmbrep.2016.49.5.041
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发表时间：
2016-05
期刊：
影响因子：
3.8
通讯作者：
Kiyono H
中科院分区：
文献类型：
--
作者：
Lee J;Park EJ;Kiyono H
肠道是最大、最复杂的免疫系统器官，其中众多免疫细胞和上皮细胞、共生微生物群和外部抗原之间的动态和相互作用有助于建立稳态和病理条件。维持肠道稳态的机制对于在肠腔恶劣环境下维持肠道健康至关重要。肠上皮细胞在创建宿主免疫细胞和管腔应激诱导剂之间相互作用的粘膜平台方面发挥着关键作用。因此，了解免疫细胞和管腔环境之间的上皮界面是更好地了解肠道稳态和炎症等病理生理学的先决条件。在这篇综述中，我们探讨了上皮在限制或促进肠道炎症（例如炎症性肠病）方面的重要性。我们还介绍了有关 microRNA 等小 RNA 如何协调病理生理基因调控的最新发现。 [2016 年 BMB 报告； 49（5）：263-269]
The intestine represents the largest and most elaborate immune system organ, in which dynamic and reciprocal interplay among numerous immune and epithelial cells, commensal microbiota, and external antigens contributes to establishing both homeostatic and pathologic conditions. The mechanisms that sustain gut homeostasis are pivotal in maintaining gut health in the harsh environment of the gut lumen. Intestinal epithelial cells are critical players in creating the mucosal platform for interplay between host immune cells and luminal stress inducers. Thus, knowledge of the epithelial interface between immune cells and the luminal environment is a prerequisite for a better understanding of gut homeostasis and pathophysiologies such as inflammation. In this review, we explore the importance of the epithelium in limiting or promoting gut inflammation (e.g., inflammatory bowel disease). We also introduce recent findings on how small RNAs such as microRNAs orchestrate pathophysiologic gene regulation. [BMB Reports 2016; 49(5): 263-269]
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