Genetic influences on oestrous cyclicity in mice: evidence that cycle length and frequency are differentially regulated.
Genetic influences on oestrous cyclicity in mice: evidence that cycle length and frequency are differentially regulated.
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DOI：
10.1530/jrf.0.0940261
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
J. Nelson;K. Karelus;L. S. Felicio;T. Johnson
中科院分区：
文献类型：
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作者：
J. Nelson;K. Karelus;L. S. Felicio;T. Johnson
对C57 BL/6 J、DBA/2 J和C3 H/HeJ小鼠以及2-5月龄的两个F1杂交品系（B6 D2 F1和B6 C3 HF 1）的研究表明，近交系之间存在显著的基因型差异。C57小鼠的正常周期（3-6天）是DBA和C3 H小鼠的三倍，这主要是由于更少的假孕样周期（7-14天）。C57小鼠的周期较DBA和C3 H小鼠长。虽然DBA和C3 H小鼠的周期频率相似，但C3 H小鼠的周期短于DBA小鼠。结果表明，周期频率的遗传决定因素与周期长度的遗传决定因素不同。杂种F_1的规则周期频率介于亲本（B_6D_2F_1）之间或与C_57（B_6C_3HF_1）相近，表明规则周期频率在亲本中表现为加性遗传变异，而在C_57背景中表现为显性变异。规则的周期短于两个亲本菌株（B6 D2 F1）或类似于其中之一（B6 C3 HF 1），表明指定短周期的基因的杂种优势和显性。虽然缺乏相互交叉意味着母体效应和可能的基因组印记效应无法评估，这些结果揭示了显着的遗传影响周期长度和频率，并表明，一些基因指定这两个性状不同。
Studies in C57BL/6J, DBA/2J and C3H/HeJ mice and in two F1 hybrid strains (B6D2F1 and B6C3HF1) 2-5 months old revealed marked genotypic differences among inbred strains. C57 mice had three times as many regular (3-6 days) cycles as DBA and C3H mice, due largely to fewer pseudopregnant-like (7-14 day) cycles. C57 had longer regular cycles than DBA and C3H mice. Although the frequencies of regular cycles of DBA and C3H mice were similar, the cycles of C3H mice were shorter than those of DBA mice. The results indicated that the genetic determinants of the frequency of regular cycles differ from those specifying cycle length. Frequency of regular cycles of F1 hybrids was either intermediate between the parent strains (B6D2F1) or similar to the C57 strain (B6C3HF1), suggesting that regular cycle frequency shows additive genetic variation in the former crosses, but mostly dominant variance in the latter background. Regular cycles were either shorter than in both parent strains (B6D2F1) or similar to one of them (B6C3HF1), indicating heterosis and dominance for genes specifying short cycles. Although the lack of reciprocal crosses meant that maternal effects and possible genomic imprinting effects could not be assessed, these results reveal marked genetic influences on cycle length and frequency and suggest that some of the genes specifying these two traits differ.