The subretinal implant: Can microphotodiode arrays replace degenerated retinal photoreceptors to restore vision?

The subretinal implant: Can microphotodiode arrays replace degenerated retinal photoreceptors to restore vision?
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DOI:
10.1159/000064650
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发表时间:
2002-01-01
期刊:
影响因子:
2.6
通讯作者:
Zrenner, E
Zrenner, E
中科院分区:
医学3区
文献类型:
--
作者:
Zrenner, E

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看是一个复杂的信息处理过程,我们通常不知道,从形成一个真实的,减少和颠倒的形象在眼睛的后面完成的眼睛的角膜和透镜。在透明视网膜的最外层中的大约1.3亿个光感受器(PR)将局部亮度和颜色图案转换成化学和电信号,其触发许多不同视网膜细胞的活动:水平细胞、双极细胞、无长突细胞和神经节细胞(GC)。这些信息通过串行和并行的途径进行处理,其中部分机制尚不清楚。这些1.3亿PR的信息被压缩到大约120万个高度专业化的GC纤维的水平。视网膜中的这120万根纤维
Seeing is a complex of information processing, of which we are normally not aware, starting with the formation of a real, reduced and up-side-down image on the back of the eye accomplished by the eye’s cornea and lens. About 130 million photoreceptors (PR) in the outermost layer of the transparent retina transform local luminance and color patterns into chemical and electrical signals which trigger activity of the many different retinal cells: horizontal cells, bipolar cells, amacrine cells and ganglion cells (GCs). The information is processed by serial and parallel pathways by in parts still unknown mechanisms. The information of these 130 million PRs is compressed to the level of approximately 1.2 million highly specialized GC fibers. These 1.2 million fibers in the retina then