Circadian rhythms and metabolism: from the brain to the gut and back again.
Circadian rhythms and metabolism: from the brain to the gut and back again.
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DOI：
10.1111/nyas.13188
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发表时间：
2016-12
影响因子：
5.2
通讯作者：
Frank E
中科院分区：
文献类型：
--
作者：
Cribbet MR;Logan RW;Edwards MD;Hanlon E;Bien Peek C;Stubblefield JJ;Vasudevan S;Ritchey F;Frank E
本文着重介绍昼夜节律系统与糖代谢的关系。跨翻译谱的研究证实了昼夜节律系统对葡萄糖代谢的重要性，并为这些系统何时以及为何出错提供了有希望的线索。特别是，基础研究已经开始澄清昼夜节律系统调节代谢的分子和遗传机制。对人类行为的研究，特别是在精神疾病的背景下，如双相情感障碍和重度抑郁症，迫使我们看到心理健康和代谢健康是如何密不可分的。我们还强调通过大数据和高级分析来推进昼夜节律科学的巨大机遇。昼夜节律研究的进展已经转化为具有巨大治疗潜力的环境和药理干预。
This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.