Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy.
Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy.
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重组人促红细胞生成素连续皮下输注对营养不良的糖尿病肾病透析前贫血患者的治疗用途。
DOI：
10.1530/eje.0.1390367
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发表时间：
1998
影响因子：
5.8
通讯作者：
Yuzuru Kato
中科院分区：
文献类型：
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作者：
M. Sohmiya;T. Kakiba;Yuzuru Kato
我们比较了连续皮下注射重组人促红细胞生成素（rhEPO）的效果。静脉输注（CSI）与每周一次皮下推注（s.c.）在5例营养不良的糖尿病肾病透析前贫血患者中，rhEPO以每周6000 IU（36 IU/h）的流量持续输注（CSI组）或皮下注射（CSI组）。在一项交叉比较研究中，以6000 IU的剂量每周一次（SBI组）给药4周，洗脱期为4周。平均值+/-S.D.血浆EPO水平从基础值18.0 ± 4.9mIU/ml增加到rhEPO CSI开始后2周的稳态值70.5 ± 38.9mIU/ml（P < 0.05）。治疗开始后3周，CSI组网织红细胞计数高于基础值的增加大于SBI组（0.94+/-0.35%vs-0.03+/-0.46%，P < 0.05）。在治疗开始后4周，CSI组Hb浓度高于基础值的增加比SBI组大得多（2.56+/-0.77 g/dl vs 0.28+/-0.62 g/dl，P < 0.05）。这些结果表明，重组人促红细胞生成素管理的CSI是更有效的改善营养不良的透析前糖尿病肾病患者的贫血比SBI。
We compared the effect of recombinant human erythropoietin (rhEPO) administration by continuous s.c. infusion (CSI) with that of a weekly bolus s.c. injection (SBI) in five malnourished predialysis anemic patients with diabetic nephropathy. rhEPO was either continuously infused at a flow rate of 6000 IU per week (36 IU/h) (CSI group) or injected s.c. at a dose of 6000 IU once a week (SBI group) for 4 weeks, in a cross-over comparative study with a washout period of 4 weeks. Mean+/-S.D. plasma EPO levels increased from a basal value of 18.0+/-4.9 mIU/ml to a steady state value of 70.5+/-38.9 mIU/ml 2 weeks after the start of CSI of rhEPO (P < 0.05). Increases in reticulocyte count above the basal value were greater in the CSI group than the SBI group at 3 weeks after the start of treatment (0.94+/-0.35% vs -0.03+/-0.46%, P < 0.05). Increases in Hb concentration above the basal value were much greater in the CSI group than the SBI group at 4 weeks after the start of treatment (2.56+/-0.77 g/dl vs 0.28+/-0.62 g/dl, P < 0.05). These findings suggest that rhEPO administration by CSI is more effective than by SBI for improving anemia in malnourished predialysis patients with diabetic nephropathy.
慢性肾衰竭贫血：重组促红细胞生成素的病理生理学和作用。
影响因子：
--
作者：
Eschbach,JW;Haley,NR;Adamson,JW
通讯作者：
Adamson,JW
影响因子：
11.2
作者：
Servidei, Tiziana;Meco, Daniela;Riccardi, Riccardo
通讯作者：
Riccardi, Riccardo