Initial plasma HIV-1 RNA levels and progression to AIDS in women and men.
Initial plasma HIV-1 RNA levels and progression to AIDS in women and men.
复制标题
DOI：
10.1056/nejm200103083441003
复制
发表时间：
2001-03-08
影响因子：
158.5
通讯作者：
Quinn, TC
中科院分区：
文献类型：
--
作者：
Sterling, TR;Vlahov, D;Quinn, TC
背景：尚不清楚感染 1 型人类免疫缺陷病毒 (HIV-1) 的男性和女性血浆病毒 RNA 水平（病毒载量）是否存在差异。在男性中，血清转化后的初始病毒载量可预测进展为获得性免疫缺陷综合症（艾滋病）的可能性，但尚未在女性中评估两者之间的关系。目前，开始抗逆转录病毒治疗的指南统一适用于女性和男性。方法：从 1988 年到 1998 年，大约每六个月对 156 名男性和 46 名女性注射吸毒者进行病毒载量和 CD4+ 淋巴细胞计数测量，这些人在 HIV-1 血清转化后进行前瞻性随访。结果：男性的初始病毒载量中位数为每毫升 50,766 个 HIV-1 RNA 拷贝，但女性中每毫升只有 15,103 个拷贝（P
Background: It is unclear whether there are differences between men and women with human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the viral load). In men, the initial viral load after seroconversion predicts the likelihood of progression to the acquired immunodeficiency syndrome (AIDS), but the relation between the two has not been assessed in women. Currently, the guidelines for initiating antiretroviral therapy are applied uniformly to women and men.Methods: From 1988 through 1998, the viral load and the CD4+ lymphocyte count were measured approximately every six months in 156 male and 46 female injection-drug users who were followed prospectively after HIV-1 seroconversion.Results: The median initial viral load was 50,766 copies of HIV-1 RNA per milliliter in the men but only 15,103 copies per milliliter in the women (P