NERVE-FIBER PROLIFERATION IN INTERSTITIAL CYSTITIS
NERVE-FIBER PROLIFERATION IN INTERSTITIAL CYSTITIS
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DOI：
10.1007/bf01605152
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
TURNERWARWICK, RT
中科院分区：
文献类型：
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作者：
CHRISTMAS, TJ;RODE, J;TURNERWARWICK, RT
间质性膀胱炎疼痛的病因尚不清楚，尽管有报道是由于肥大细胞颗粒释放介质所致。溶囊和膀胱内滴注二甲亚砜已被证明可以缓解这种情况下的疼痛。我们使用蛋白质基因产物 9.5 的免疫组织化学染色研究了膀胱壁内的神经群。慢性间质性膀胱炎组18例，对照组12例；研究对象包括神经性膀胱炎 (n=1)、慢性细菌性膀胱炎 (n=3)、系统性红斑狼疮性膀胱炎 (n=2) 和正常膀胱炎 (n=6)。慢性间质性膀胱炎的尿路上皮下肌层和逼尿肌层内的神经纤维明显多于正常人。患有其他病因的慢性膀胱炎的患者膀胱壁内的神经纤维密度没有显着增加，这表明神经纤维增殖与间质性膀胱炎之间存在特定关联。 溶胞作用被证明可以选择性地消耗粘膜下神经丛，而不改变逼尿肌内的神经密度。这一发现解释了术后膀胱脱敏而不损害逼尿肌功能的原因。
The aetiology of pain in interstitial cystitis is not understood, although it has been reported to be due to release of mediators from mast cell granules. Cystolysis and intravesical instillation of dimethyl sulphoxide have been shown to relieve pain in this condition. We have studied the nerve population within the bladder wall using immunohistochemical stains for protein gene product 9.5. A group of 18 cases of chronic interstitial cystitis and 12 controls; neuropathic bladder (n=1), chronic bacterial cystitis (n=3), systemic lupus erythematosus cystitis (n=2) and normals (n=6), were investigated. There were significantly more nerve fibres within the sub-urothelial and detrusor muscle layers in chronic interstitial cystitis than there were in normals. Patients with chronic cystitis of other aetiology did not have a significant increase in nerve fibre density within the bladder wall suggesting a specific association between nerve fibre proliferation and interstitial cystitis. Cystolysis is shown to deplete selectively the submucosal nerve plexuses without altering the nerve density within detrusor muscle. This finding explains the desensitisation of the bladder without impairment of detrusor function after this procedure.