Revealing plant defense signaling
Revealing plant defense signaling
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DOI：
10.4161/psb.6.10.17345
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发表时间：
2011-10
影响因子：
2.9
通讯作者：
T. Xing;A. Laroche
中科院分区：
文献类型：
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作者：
T. Xing;A. Laroche
植物与病原体相互作用的调控机制是复杂的、动态的。蛋白质组学方法对于理解调控网络是必要的，因为它可以识别与其功能相关的新蛋白质，并最终旨在阐明它们的表达、积累和修饰是如何被控制的。蛋白质磷酸化是植物与病原体相互作用中蛋白质活性的主要控制机制之一，对蛋白质磷酸化在植物与病原体相互作用中的重要性的理解可能是压倒性的。由于任何单一植物基因组中蛋白激酶和磷酸酶的数量众多，以及任何技术的特定限制，对我们来说，充分描绘磷酸化机制是极具挑战性的。目前的蛋白质组学方法和技术进步已经证明了它们在识别新成分方面的巨大潜力。近年来对发达的植物-病原体系统的研究揭示了新的磷酸化途径，其中一些磷酸化途径不是核心磷酸化级联。需要更多的磷蛋白组学研究来增加我们对宿主对病原体攻击的抗性反应的不同机制及其微调的理解。
The regulation mechanisms of any plant-pathogen interaction are complex and dynamic. A proteomic approach is necessary in understanding regulatory networks because it identifies new proteins in relation to their function and ultimately aims to clarify how their expression, accumulation and modification is controlled. One of the major control mechanisms for protein activity in plant-pathogen interactions is protein phosphorylation, and an understanding of the significance of protein phosphorylation in plant-pathogen interaction can be overwhelming. Due to the high number of protein kinases and phosphatases in any single plant genome and specific limitations of any technologies, it is extremely challenging for us to fully delineate the phosphorylation machinery. Current proteomic approaches and technology advances have demonstrated their great potential in identifying new components. Recent studies in well-developed plant-pathogen systems have revealed novel phosphorylation pathways, and some of them are off the core phosphorylation cascades. Additional phosphoproteomic studies are needed to increase our comprehension of the different mechanisms and their fine tuning involved in the host resistance response to pathogen attacks.