Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population
Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population
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中国汉族人群哮喘和过敏性鼻炎儿童TNFSF4和FAM167A-BLK多态性的遗传风险
DOI：
10.3109/02770903.2015.1108437
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发表时间：
2016-01-01
影响因子：
1.9
通讯作者：
Hong, Su-Ling
中科院分区：
文献类型：
--
作者：
Liu, Yun;Ke, Xia;Hong, Su-Ling
摘要背景：哮喘和变应性鼻炎(AR)是上呼吸道的常见病、多发病。最近发现，TNFSF4和FAM167A-BLK基因的单核苷酸多态(SNPs)与多种免疫相关疾病有关。目的：探讨中国汉族人群中TNFSF4或FAM167A-BLK基因多态性与哮喘和变应性鼻炎的遗传易感性。方法：对290例哮喘儿童和252例健康儿童进行病例对照研究。用聚合酶链式反应-限制性片段长度多态分析方法检测了肿瘤坏死因子4区(rs1234313、rs1234314、rs1234315、rs1 2039904、rs844648和rs1 0912580)和FAM167A-BLK区(rs2254546、rs13277113和rs1600249)的9个SNP。结果：TnFSF4的3个SNP(rs1 234313、rs1 234314和rs1 234315)和FAM167A-BLK的2个SNP(rs2254546和rs1 600249)与哮喘和AR显著相关，而rs1 600249与哮喘无变应性鼻炎相关。此外，我们还展示了TNFSF4和FAM167A-BLK SNPs之间的协同效应。结论：TNFSF4和FAM167A-BLK基因的SNPs可能与中国汉族人群哮喘和AR基因风险有关。
Abstract Background: Asthma and allergic rhinitis (AR) frequently occur as comorbid diseases of the upper airways. Single-nucleotide polymorphisms (SNPs) in the TNFSF4 and FAM167A-BLK genes have recently been shown to be associated with various immune-related disorders. Objective: Our aim was to determine whether TNFSF4 or FAM167A-BLK polymorphisms confer genetic susceptibility to asthma and AR in a Han Chinese population. Methods: We performed a case–control study of 290 asthmatic children and 252 healthy controls. Nine SNPs in the TNFSF4 region (rs1234313, rs1234314, rs1234315, rsl 2039904, rs844648 and rsl 0912580) and the FAM167A-BLK region (rs2254546, rs13277113 and rs1600249) were detected using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: This study revealed that three SNPs in TNFSF4 (rsl 234313, rsl 234314 and rsl 234315) and two SNPs in FAM167A-BLK (rs2254546 and rsl 600249) were significantly correlated with asthma and AR, while SNP rsl600249 was associated with asthma without allergic rhinitis as a risk factor. Further, we demonstrated synergistic effects between the TNFSF4 and FAM167A-BLK SNPs. Conclusion: This study supports that the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and AR gene risk in the Han Chinese cohort.