Global Gene Expression Profiling in Infants With Acute Respiratory Syncytial Virus Broncholitis Demonstrates Systemic Activation of Interferon Signaling Networks
Global Gene Expression Profiling in Infants With Acute Respiratory Syncytial Virus Broncholitis Demonstrates Systemic Activation of Interferon Signaling Networks
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DOI：
10.1097/inf.0b013e318278b4b3
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发表时间：
2013-02-01
影响因子：
3.6
通讯作者：
Belmont, John W.
中科院分区：
文献类型：
--
作者：
Bucasas, Kristine L.;Mian, Asad I.;Belmont, John W.
背景资料：呼吸道合胞病毒（RSV）是儿科下呼吸道感染的主要原因，对儿科急诊利用率有很大影响。宿主反应的变化可能影响发病机制和疾病的严重程度。我们评估了总体基因表达谱，以更好地了解婴幼儿急性RSV毛细支气管炎的全身宿主反应。
Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric lower respiratory tract infections and has a high impact on pediatric emergency department utilization. Variation in host response may influence the pathogenesis and disease severity. We evaluated global gene expression profiles to better understand the systemic host response to acute RSV bronchiolitis in infants and young children.Methods: Patients (age