Prevalence of hepatitis C virus antibody in a liver transplantation population.
Prevalence of hepatitis C virus antibody in a liver transplantation population.
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肝移植人群中丙型肝炎病毒抗体的患病率。
DOI：
10.1007/bf01300295
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发表时间：
1992
影响因子：
3.1
通讯作者：
VanThiel,DH
中科院分区：
文献类型：
--
作者：
el-Ashmawy,L;Hassanein,T;Gavaler,JS;VanThiel,DH
针对丙型肝炎病毒（anti-HCV）抗原（C-100-3）的抗体的血清学检测技术的发展，是长期寻找非甲、非乙（NANB）肝炎病原体的重大突破。HCV在终末期肝病患者中的发病率尚不清楚。此外，肝移植后的复发率（OLTx）和由于OLTx经历而获得新的HCV感染率尚不清楚。这项研究就是为了回答这些问题。确定了匹兹堡大学372例接受OLTx的患者中HCV的患病率。乙肝相关肝病合并肝癌的移植患者HCV抗体阳性率最高（45.4%），其次是代谢性肝病（42.5%）、推定的NANB肝病（41.4%）和隐源性肝硬化（20.9%）；胆汁淤积性肝病患者的发病率最低（16.2%）。HCV抗体阳性仅占肝癌患者的26.3%。在移植前阴性的患者中，12.2%的患者在oltx后获得HCV抗体。在假定的NANB组中，移植前HCV抗体阳性或阴性患者的AST和ALT均未检测到差异。在隐源性肝硬化患者中，HCV抗体阳性的患者在移植前的转氨酶水平高于HCV抗体阴性的患者。
The development of a serologic assay to detect antibodies directed at an antigen (C-100-3) of the hepatitis C virus (anti-HCV) has been a major breakthrough in the long search for causative agents of non-A, non-B (NANB) hepatitis. The frequency of HCV in those who have end-stage liver disease is not known. Moreover, the rate of recurrence after liver transplantation (OLTx) and the rate of acquisition of new HCV infection as a result of the OLTx experience is as yet unknown. This study was performed in an attempt to answer these questions. The prevalence of HCV in 372 patients undergoing OLTx at the University of Pittsburgh was determined. Those transplanted for HBV-related liver disease with hepatoma had the highest rate of HCV antibody positivity (45.4%) followed by those with metabolic liver disease (42.5%), putative NANB liver disease (41.4%), and cryptogenic cirrhosis (20.9%); those with cholestatic liver disease exhibited the lowest rate (16.2%). HCV antibody was positive in only 26.3% of patients with hepatoma. Of those patients who were negative prior to transplantation, 12.2% acquired HCV antibody post-OLTx. In the putative NANB group, no difference was detected in the AST and ALT prior to transplantation in either the HCV antibody-positive or-negative patients. In patients with cryptogenic cirrhosis, those who were positive for HCV antibody had higher transaminase levels prior to transplantation than did those patients who were HCV antibody negative.