INOSITOL 1,4,5-TRISPHOSPHATE AND 5'-GTP INDUCE CALCIUM RELEASE FROM DIFFERENT INTRACELLULAR POOLS
INOSITOL 1,4,5-TRISPHOSPHATE AND 5'-GTP INDUCE CALCIUM RELEASE FROM DIFFERENT INTRACELLULAR POOLS
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DOI：
10.1016/0014-5793(87)81037-2
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发表时间：
1987-06-22
期刊：
影响因子：
3.5
通讯作者：
SOLING, HD
中科院分区：
文献类型：
--
作者：
HENNE, V;PIIPER, A;SOLING, HD
最近几个研究小组已经证明，5′-GTP可以通过一种似乎与Ins（1，4，5）P3不同的机制，独立于1，4，5-三磷酸肌醇（Ins（1，4，5）P3）从细胞内隔室释放钙。我们首次报道了5′-GTP-敏感性和Ins（1，4，5）P3-敏感性钙池位于不同的细胞内区室。
It has been shown recently by several groups that 5′‐GTP can release calcium from intracellular compartments independently from inositol 1,4,5‐trisphosphate (Ins(1,4,5)P3) by a mechanism which seems to be different from that used by Ins(1,4,5)P3. We report here for the first time that the 5′‐GTP‐sensitive and the Ins(1,4,5)P3‐sensitive calcium pools reside in different intracellular compartments.