Quantitative electroencephalography in a swine model of blast-induced brain injury
Quantitative electroencephalography in a swine model of blast-induced brain injury
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DOI：
10.1080/02699052.2016.1216603
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发表时间：
2017-01-01
期刊：
影响因子：
1.9
通讯作者：
King, Albert I.
中科院分区：
文献类型：
--
作者：
Chen, Chaoyang;Zhou, Chengpeng;King, Albert I.
目的：通过建立猪冲击波模型，利用脑电(EEG)检测冲击波暴露后早期脑电活动的异常，建立定量脑电数据分析方案。分别于爆炸前15分钟、爆炸后15分钟、30分钟、2小时、1天、2天和3天进行脑电记录，采用Biopac四通道数据采集系统。结果：冲击波暴露后早期qEEG改变，包括平均波幅(MAMP)降低、Delta频段功率增加、α频段均方根(RMS)减小和90%谱边缘频率(SEF90)降低。结论：本研究证实了定量脑电对脑损伤的敏感性。爆炸后早期qEEG的变化提示多参数脑电地形图可用于冲击性脑损伤的诊断。早期发现冲击性脑损伤将使士兵能够及早筛查和评估大脑异常，从而能够及时进行治疗干预。
Objective: Electroencephalography (EEG) was used to examine brain activity abnormalities earlier after, blast exposure using a swine model to develop a qEEG data analysis protocol.Methods: Anaesthetized swine were exposed to 420-450 Kpa blast overpressure and survived for 3 days after blast. EEG recordings were performed at 15 minutes before the blast and 15 minutes, 30 minutes, 2 hours and 1, 2 and 3 days post-blast using surface recording electrodes and a Biopac 4-channel data acquisition system. Off-line quantitative EEG (qEEG) data analysis was performed' to determine qEEG changes.Results: Blast induced qEEG changes earlier after blast exposure, including a decrease of mean amplitude (MAMP), an increase of delta band power, a decrease of alpha band root mean square (RMS) and a decrease of 90% spectral edge frequency (SEF90).Conclusions: This study demonstrated that qEEG is sensitive for cerebral injury. The changes of qEEG earlier after the blast indicate the potential of utilization of multiple parameters of gEEG for diagnosis of blast-induced brain injury. Early detection of blast induced brain injury will allow early screening and assessment of brain abnormalities in soldiers to enable timely therapeutic intervention.