Basophils: a potential liaison between innate and adaptive immunity.
Basophils: a potential liaison between innate and adaptive immunity.
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DOI：
10.2332/allergolint.55.99
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发表时间：
2006-06-01
期刊：
影响因子：
--
通讯作者：
Paul, William E
中科院分区：
文献类型：
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作者：
Min, Booki;Le Gros, Graham;Paul, William E
天然免疫的激活与保护性获得性免疫反应的发展密切相关。在揭示先天免疫和Th1型获得性免疫反应之间的联系方面已经取得了重大进展。相比之下，先天免疫在Th2型获得性免疫反应发展中的作用仍不是很清楚。先天类型细胞产生IL-4，这是诱导Th2免疫的关键细胞因子，是这种先天与Th2免疫联系的诱人机制。我们最近报道，在感染肠道线虫的过程中，嗜碱性粒细胞在肝/脾中聚集，并且这些嗜碱性粒细胞表现出增强的IL-4产生。因此，嗜碱性粒细胞是介导Th2应答的先天适应性连接的一个有吸引力的候选细胞，了解感染过程中嗜碱性粒细胞对组织归巢模式和细胞因子应答的控制可能对体内诱导Th2获得性免疫具有重要意义。
Activation of innate immunity is closely associated to development of protective adaptive immune response. Significant advances have been made to reveal such links between innate immunity and Th1 type adaptive immune responses. By contrast, the role of innate immunity in the development of Th2 type adaptive immune responses is still not well understood. Production of IL-4, a key cytokine in the induction of Th2 immunity, by innate type cells represents an attractive mechanism for such an innate link to Th2 immunity. We have recently reported that in the course of infection with the intestinal nematode, Nippostrongylus brasiliensis, a robust basophil accumulation in the liver/spleen occurs and that these basophils display enhanced IL-4 production. Thus, the basophils is an attractive candidate to mediate the innate-adaptive link for Th2 responses and understanding the control of the tissue homing patterns and cytokine responses of basophils in the course of infections may shed important light on the in vivo induction of Th2 adaptive immunity.