Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug.
Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug.
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应用 LC-MS/MS 鉴定促胃动力药物莫沙必利中的极性杂质。
DOI：
10.1016/s0731-7085(03)00076-1
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发表时间：
2003
影响因子：
3.4
通讯作者：
K. Vyas
中科院分区：
文献类型：
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作者：
Y. Kumar;J. Moses Babu;M. Sarma;B. Seshidhar;S. Reddy;G. Reddy;K. Vyas
在莫沙必利的杂质谱中，在HPLC中检测到莫沙必利的极性杂质（0.1%）。根据LC-MS/MS分析获得的质谱数据，将该杂质结构表征为4-氨基-5-氯-2-乙氧基-N-[[（4-苄基）-2-吗啉基]甲基]苯甲酰胺。值得注意的是，该杂质是莫沙必利的强效类似物，其促胃动力活性远高于甲氧氯普胺。该杂质是通过明确的路线合成的，并通过收集各种光谱数据证实了结构，并讨论了形成过程。据我们所知，该化合物在其他地方未报告为工艺杂质。
In the impurity profile of mosapride a polar impurity (0.1%) was detected in HPLC with respect to mosapride. Based on the mass spectral data obtained by LC–MS/MS analysis this impurity structure was characterised as 4-amino-5-chloro-2-ethoxy-N-[[(4-benzyl)-2-morphinyl] methyl] benzamide. It is interesting to note that this impurity is potent analogue of mosapride, which will have much higher gastroprokinetic activity than metoclopramide. This impurity was synthesised from an unambiguous route and confirmed the structure by collecting various spectral data and the formation is discussed. To our knowledge this compound was not reported as process impurity elsewhere.
豚鼠回肠中 5-羟色胺神经元受体的药理学特征，其性质与 5-羟色胺受体相似。
DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Craig,DA;Clarke,DE
通讯作者：
Clarke,DE