Facile fabrication of multistimuli-responsive metallo-supramolecular core cross-linked block copolymer micelles.
Facile fabrication of multistimuli-responsive metallo-supramolecular core cross-linked block copolymer micelles.
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DOI：
10.1002/marc.201300072
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发表时间：
2013-06
影响因子：
4.6
通讯作者：
Zhishen Ge;Shiyong Liu
中科院分区：
文献类型：
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作者：
Zhishen Ge;Shiyong Liu
金属超分子核交联 (CCL) 胶束由三联吡啶官能化双亲水性嵌段共聚物、聚(2-(2-甲氧基乙氧基)乙基甲基丙烯酸酯)-b-聚(2-(二乙氨基)乙基)制成 甲基丙烯酸酯-co-4'-(6-甲基丙烯酰氧基己氧基)-2,2':6',2"-三联吡啶) [PMEO2 MA-b-P(DEA-co-TPHMA)] 通过形成双(三联吡啶)钌(II)络合物。这些金属超分子 CCL 胶束不仅在水溶液中的不同 pH 值和温度下表现出高结构完整性，而且具有多重刺激响应性，包括 pH 响应核、热响应壳，以及在添加竞争性金属离子螯合剂后双（三联吡啶）钌（II）配合物的可逆解离，从而可以精确控制释放 通过不同刺激的组合封装疏水性客体分子。
Metallo-supramolecular core cross-linked (CCL) micelles are fabricated from terpyridine-functionalized double hydrophilic block copolymers, poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-4'-(6-methacryloxyhexyloxy)-2,2':6',2″-terpyridine) [PMEO2 MA-b-P(DEA-co-TPHMA)] via the formation of bis(terpyridine)ruthenium(II) complexes. These metallo-supramolecular CCL micelles exhibit not only high structural integrity under different pH values and temperatures in aqueous solution, but multistimuli responsiveness including pH-responsive cores, thermo-responsive shells, and reversible dissociation of bis(terpyridine)ruthenium(II) complexes upon addition of competitive metal ion chelator, which allows for precisely controlled release of the encapsulated hydrophobic guest molecules via the combination of different stimuli.