Staphylococcus aureus with reduced susceptibility to vancomycin
Staphylococcus aureus with reduced susceptibility to vancomycin
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DOI：
10.1086/422458
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发表时间：
2004-08-15
影响因子：
11.8
通讯作者：
Perl, TM
中科院分区：
文献类型：
--
作者：
Cosgrove, SE;Carroll, KC;Perl, TM
对万古霉素敏感性降低的金黄色葡萄球菌感染仍有报道，包括2例由葡萄球菌引起的病例。对万古霉素完全耐药的金黄色葡萄球菌分离株。本文首先概述了万古霉素中间体S的定义。金黄色葡萄球菌（VISA）和万古霉素耐药的S.金黄色葡萄球菌（VRSA）和感染的危险因素。接下来，我们描述了耐药性的机制和实验室检测方法。最后，我们将讨论与VISA和VRSA隔离相关的感染控制和管理问题。
Infections with Staphylococcus aureus with reduced susceptibility to vancomycin continue to be reported, including 2 cases caused by S. aureus isolates with full resistance to vancomycin. This review first outlines the definitions of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) and risk factors for infection. Next, we describe the mechanisms of resistance and methods of laboratory detection of the organisms. Finally, we address infection control and management issues associated with isolation of VISA and VRSA.