Disease Burden and Variability in Sarcoidosis
Disease Burden and Variability in Sarcoidosis
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DOI：
10.1513/annalsats.201707-564ot
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发表时间：
2017-12-01
影响因子：
8.3
通讯作者：
Koth, Laura L.
中科院分区：
文献类型：
--
作者：
Gerke, Alicia K.;Judson, Marc A.;Koth, Laura L.
结节病是一种全身性炎症性疾病，发病率高，死亡率增加。作为国家心脏、肺和血液研究所研讨会的一部分，为了更好地了解这种疾病并改善结节病患者的预后，我们回顾了美国关于这种疾病的医疗负担和预后的现有数据。结果存在种族，民族，性别和社会经济群体的差异，非洲裔美国人患有不成比例的更严重的疾病。非裔美国人的死亡率最高，但在白色人中可能会增加。结节病的卫生保健负担不是由其躯体表现来定义的，但也受到与这种疾病相关的心理社会，经济和共病状况的极大影响。疲劳、抑郁、认知功能障碍、治疗副作用和疼痛综合征在该人群中非常普遍，并导致不良结局。对患者和社会的直接和间接经济成本可能也很大，尽管没有很好的定义。我们建议利用现有和未来的技术和基础设施，更准确地定义和监测美国结节病引起的总体医疗负担和患者结局。
Sarcoidosis is a systemic inflammatory disease with substantial morbidity and increasing mortality. As part of the National Heart, Lung, and Blood Institute's workshop to better understand this disease and improve the outcomes of patients with sarcoidosis, we reviewed the available data on health care burden and outcomes of this disease in the United States. Disparities in outcomes exist by race, ethnicity, sex, and socioeconomic groups, with African Americans having disproportionately more severe disease. Mortality rates are highest in African Americans, but may be increasing in white individuals. The health care burden of sarcoidosis is defined not by its somatic manifestations, but is also greatly impacted by psychosocial, economic, and comorbid conditions associated with this disease. Fatigue, depression, cognitive dysfunction, treatment side effects, and pain syndromes are highly prevalent in this population and contribute to poor outcomes. The direct and indirect economic costs to patients and society are likely also substantial, although not well defined. We recommend leveraging existing and future technology and infrastructure to more accurately define and monitor the overall total sarcoidosis-attributable health care burden and patient outcomes in the United States.