Chronic Stress Alters Glucocorticoid Receptor and Mineralocorticoid Receptor mRNA Expression in the European Starling (Sturnus vulgaris) Brain
Chronic Stress Alters Glucocorticoid Receptor and Mineralocorticoid Receptor mRNA Expression in the European Starling (Sturnus vulgaris) Brain
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DOI：
10.1111/j.1365-2826.2009.01908.x
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Meddle, S. L.
中科院分区：
文献类型：
--
作者：
Dickens, M.;Romero, L. M.;Meddle, S. L.
虽然糖皮质激素对急性短期应激的反应是一种适应性生理机制，有助于对有害刺激的反应和生存，但慢性应激与对健康的负面影响有关。在野生捕获的欧洲椋鸟（Sturnus vulgaris），慢性应激改变下丘脑-垂体-肾上腺（HPA）轴的反应性，急性皮质酮反应。在本研究中，我们研究了潜在的神经内分泌机制，通过比较糖皮质激素受体和盐皮质激素受体mRNA的表达在大脑中的慢性和非慢性应激八哥。下丘脑室旁核，而不是海马，糖皮质激素受体mRNA的表达在慢性应激的鸟类显着低于对照组相比，这表明皮质酮负反馈的疗效的变化。此外，慢性应激的鸟类表现出海马MR mRNA表达的显着下降。总之，这些结果表明，慢性应激改变了野生鸟类的脑生理学，并为理解慢性应激导致野生动物HPA轴失调的潜在机制提供了重要信息。
Although the glucocorticoid response to acute short-term stress is an adaptive physiological mechanism that aids in the response to and survival of noxious stimuli, chronic stress is associated with a negative impact on health. In wild-caught European starlings (Sturnus vulgaris), chronic stress alters the responsiveness of hypothalamic-pituitary-adrenal (HPA) axis as measured by the acute corticosterone response. In the present study, we investigated potential underlying neuroendocrine mechanisms by comparing glucocorticoid receptor and mineralocorticoid receptor mRNA expression in the brains of chronically and nonchronically-stressed starlings. Hypothalamic paraventricular nucleus, but not hippocampal, glucocorticoid receptor mRNA expression in chronically-stressed birds was significantly lower compared to controls, suggesting changes in the efficacy of corticosterone negative feedback. In addition, chronically-stressed birds showed a significant decrease in hippocampal MR mRNA expression. Together, these results suggest that chronic stress changes the brain physiology of wild birds and provides important information for the understanding of the underlying mechanisms that result in dysregulation of the HPA axis in wild animals by chronic stress.