Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases.
Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases.
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DOI：
10.3389/fphys.2022.953078
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发表时间：
2022
影响因子：
4
通讯作者：
Fang, Jie
中科院分区：
文献类型：
--
作者：
Pan, Zijian;Dong, Hao;Huang, Ning;Fang, Jie
Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively studied in regulating ageing and age-related diseases. Sirtuins are also pivotal modulators in oxidative stress and inflammation, as they can regulate the expression and activation of downstream transcriptional factors (such as Forkhead box protein O3 (FOXO3a), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB)) as well as antioxidant enzymes, through epigenetic modification and post-translational modification. Most importantly, studies have shown that aberrant sirtuins are involved in the pathogenesis of infectious and inflammatory oral diseases, and oral cancer. In this review, we provide a comprehensive overview of the regulatory patterns of sirtuins at multiple levels, and the essential roles of sirtuins in regulating inflammation, oxidative stress, and bone metabolism. We summarize the involvement of sirtuins in several oral diseases such as periodontitis, apical periodontitis, pulpitis, oral candidiasis, oral herpesvirus infections, dental fluorosis, and oral cancer. At last, we discuss the potential utilization of sirtuins as therapeutic targets in oral diseases.
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影响因子：
4.6
作者：
Chen X;Sun K;Jiao S;Cai N;Zhao X;Zou H;Xie Y;Wang Z;Zhong M;Wei L
通讯作者：
Wei L
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
11.2
作者：
Deckers, M;van Dinther, M;ten Dijke, P
通讯作者：
ten Dijke, P
影响因子：
4.8
作者：
Cohen-Kfir, Einav;Artsi, Hanna;Dresner-Pollak, Rivka
通讯作者：
Dresner-Pollak, Rivka
影响因子：
13.5
作者：
Dai H;Sinclair DA;Ellis JL;Steegborn C
通讯作者：
Steegborn C