Carbohydrate Functionalization of Few-Layer Graphene through Microwave-Assisted Reaction of Perfluorophenyl Azide
Carbohydrate Functionalization of Few-Layer Graphene through Microwave-Assisted Reaction of Perfluorophenyl Azide
复制标题
全氟苯基叠氮化物微波辅助反应对少层石墨烯进行碳水化合物功能化
DOI：
10.1021/acsabm.8b00597
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发表时间：
2019-01-22
影响因子：
4.7
通讯作者：
Yan, Mingdi
中科院分区：
文献类型：
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作者：
Kong, Na;Park, JaeHyeung;Yan, Mingdi
石墨烯优异的物理和化学性质使其成为一种有吸引力的纳米材料和高性能纳米复合材料的组成部分。为了制备石墨烯基纳米复合材料，化学官能化通常是必要的。碳水化合物等水溶性配体不仅使功能化的石墨烯与水介质相容，而且引入生物识别，这对于石墨烯在生物技术中的应用是重要的。在这项研究中，我们报告了通过微波辅助全氟苯基叠氮（PFPA）反应用碳水化合物衍生少层石墨烯（FLG）。首先在微波辐射下用PFPA处理FLG。随后与糖基胺缀合得到碳水化合物呈递FLG。热重分析表明，微波辐射给出了更高的官能化程度相比，常规加热，具有较高的重量损失PFPA和曼配体。碳水化合物（甘露糖和半乳糖）保留其生物活性，如凝集素结合试验所示。通过微波辐射制备的碳水化合物功能化的FLG比常规加热获得了更高程度的凝集素结合。
The excellent physical and chemical properties of graphene make it an attractive nanomaterial and a component in high-performance nanocomposite materials. To prepare graphene-based nanocomposite materials, chemical functionalization is often necessary. Water-soluble ligands such as carbohydrates not only make the functionalized graphene compatible with aqueous media, but also introduce biorecognition, which is important for graphene to be used in biotechnology. In this study, we report the derivatization of few-layer graphene (FLG) with carbohydrates through microwave-assisted reaction of perfluorophenyl azide (PFPA). FLG was first treated with PFPA under microwave radiation. Subsequent conjugation with glycosyl amine gave carbohydrate-presenting FLG. Thermogravimetric analysis showed that microwave radiation gave a higher degree of functionalization compared to conventional heating, with higher weight losses for both PFPA and Man ligands. The carbohydrates (mannose and galactose) retained their bioactivity, as demonstrated by the lectin binding assays. Higher degree of binding toward lectins was obtained for the carbohydrate-functionalized FLG prepared by microwave radiation than the conventional heating.