CD30-positive EBV-associated diffuse large B-cell lymphoma occurring after immunosuppressive therapy for T-cell prolymphocytic leukemia.
CD30-positive EBV-associated diffuse large B-cell lymphoma occurring after immunosuppressive therapy for T-cell prolymphocytic leukemia.
复制标题
CD30 阳性 EBV 相关弥漫性大 B 细胞淋巴瘤在 T 细胞幼淋巴细胞白血病免疫抑制治疗后发生。
DOI：
--
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
E. Winer
中科院分区：
文献类型：
--
作者：
A. Alduaij;D. Treaba;E. Winer
我们描述了一位的病例，他在诊断和治疗T细胞前淋巴细胞白血病(T-PLL)后不到一年就发展成弥漫性大B细胞淋巴瘤(DLBCL)。确诊T-PLL时，白细胞计数为38.2×10(9)/L，体检仅发现少量小淋巴结。无肝脾肿大或皮肤损害。91%的循环前淋巴细胞经流式细胞仪免疫表型分析为CD_2、CD_3、CD_5、CD_7阳性，CD_4、CD_8共表达(绝对数，33.4×10(9)/L)。聚合酶链式反应检测T细胞受体β和γ基因重排。患者接受了化疗，但并未完全实现细胞遗传学缓解。在诊断出T-PLL 9个月后，他接受了左侧腹股沟一个新的7厘米肿块的手术切除，并被诊断为CD30阳性的EB病毒(EBV)相关性DLBCL。
We describe the case of a 64-year-old man who developed diffuse large B-cell lymphoma (DLBCL) in less than a year after he was diagnosed and treated for T-cell prolymphocytic leukemia (T-PLL). At the time of diagnosis of T-PLL he had a white blood cell count (WBC) of 38.2×10(9)/L and only few small lymph nodes were identified on physical examination. Hepatosplenomegaly or skin lesions were not present. Peripheral blood examination was remarkable for 91% circulating prolymphocytes, which by flow cytometry immunophenotypic analysis were CD2, CD3, CD5, and CD7 positive and coexpressed CD4 and CD8 (absolute number, 33.4×10(9)/L). T-cell receptor (TCR) β and γ genes rearrangements were identified by polymerase chain reaction (PCR). The patient underwent chemotherapy, but did not completely achieve cytogenetic remission. Nine months after his diagnosis of T-PLL, he underwent surgical excision of a new 7 cm left inguinal mass, and was diagnosed with CD30 positive Epstein-Barr Virus (EBV)-associated DLBCL.
周围 T 细胞淋巴瘤并发大 B 细胞增殖。
DOI：
10.1309/72cm-kaxf-66de-4xva
发表时间：
2000
期刊：
American journal of clinical pathology.
影响因子：
--
作者：
Higgins,JP;vandeRijn,M;Jones,CD;Zehnder,JL;Warnke,RA
通讯作者：
Warnke,RA