Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis
Embryonal carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis
复制标题
卵巢胚胎癌。
作者：
R. Kurman;H. Norris
本文描述了15例卵巢生殖细胞瘤的临床和病理特征。该肿瘤类似于成人睾丸胚胎性癌，根据其组织学和免疫组织化学特征可与内胚层窦瘤相鉴别。用间接免疫过氧化物酶标法对10例肿瘤石蜡包埋组织中人绒毛膜促性腺激素(HCG)和甲胎蛋白(AFP)进行了定位，10例肿瘤均为HCG，7例为AFP。人绒毛膜促性腺激素仅存在于类似合体滋养细胞的细胞中，而甲胎蛋白仅存在于单核胚胎细胞中，表明这两种蛋白抗原定位于不同的细胞类型。有9例(60%)患者有异常的激素表现，包括性早熟、不规则出血、闭经或多毛。整个组的精算存活率为39%；对于I期肿瘤患者，存活率为50%。我们建议将这种肿瘤命名为“胚胎性癌”，以区别于更常见的卵巢内胚层窦瘤，并强调其与成人睾丸胚胎性癌的组织学相似性。
The clinical and pathologic features of 15 examples of a hitherto undescribed germ cell tumor of the ovary are delineated. This tumor resembles the embryonal carcinoma of the adult testis and may be distinguished from the endodermal sinus tumor on the basis of its histologic and immunohistochemical characteristics. An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha‐fetoprotein (AFP) was done on formalin‐fixed paraffin‐embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in seven. HCG was identified only in cells resembling syncytiotrophoblast, whereas AFP was present only in mono‐nuclear embryonal cells, indicating that the two protein antigens were localized in different cell types. Abnormal hormonal manifestations, consisting of precocious puberty, irregular bleeding, amenorrhea, or hirsutism, were present in nine (60%) of the patients. The actuarial survival for the entire group was 39%; for those with stage I tumors, 50%. We are proposing the term “embryonal carcinoma” for this neoplasm in order to distinguish it from the more common endodermal sinus tumor of the ovary and to emphasize the histologic similarity to embryonal carcinoma of the adult testis.