The ATP paradox is the expression of an economizing fuel mechanism
The ATP paradox is the expression of an economizing fuel mechanism
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DOI：
10.1074/jbc.m410479200
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发表时间：
2004-12-31
影响因子：
4.8
通讯作者：
del Valle, AE
中科院分区：
文献类型：
--
作者：
Aledo, JC;del Valle, AE
长期以来，在酵母中观察到的糖酵解通量和细胞内ATP浓度之间的强负相关性一直是一个有趣的和违反直觉的现象，这被称为ATP悖论。在本文中，使用不可逆热力学的原理表明，如果ATP消耗途径对细胞外葡萄糖比糖酵解更敏感，则在添加葡萄糖时，糖酵解性能可以从有效的工作状态切换到耗散状态，反之亦然，这取决于葡萄糖的可用性。有效状态代表了高输出功率和低耗散之间的良好折衷，而耗散工作状态提供了更高的输出功率，尽管以高葡萄糖成本。这种开关策略的生理和进化的影响进行了讨论。
The strong negative correlation between glycolytic flux and intracellular ATP concentration observed in yeast has long been an intriguing and counterintuitive phenomenon, which has been referred to as the ATP paradox. Herein, using principles of irreversible thermodynamics it was shown that if the ATP-consuming pathways are more sensitive to extracellular glucose than glycolysis, then upon glucose addition glycolysis performance can switch from an efficient working regime to a dissipative regime, and vice versa, depending on glucose availability. The efficient regime represents a good compromise between high output power and low dissipation, whereas the dissipative working regime offers a higher output power although at a high glucose cost. The physiological and evolutionary implications of this switch strategy are discussed.