Age-related amyloidosis outside the brain: A state-of-the-art review
Age-related amyloidosis outside the brain: A state-of-the-art review
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大脑外与年龄相关的淀粉样变性：最新综述
DOI：
10.1016/j.arr.2021.101388
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发表时间：
2021
期刊：
影响因子：
13.1
通讯作者：
Ueda M.
中科院分区：
文献类型：
--
作者：
Tasaki M;Lavatelli F;Obici L;Obayashi K;Miyamoto T;Merlini G;Palladini G;Ando Y;Ueda M.
在大脑内外，淀粉样蛋白纤维的积累在阿尔茨海默病和帕金森病以及野生型转甲状腺素淀粉样变性等与年龄相关的致命疾病的发病机制中发挥着关键作用。虽然所有淀粉样变性的发病率随着年龄的增长而增加，但对于某些类型的淀粉样变性来说，衰老被认为是主要的直接危险因素，而这些类型的淀粉样变性通常是老年人的疾病。已知的引起老年性淀粉样变性的前体蛋白有10多种；这些蛋白包括淀粉样蛋白β蛋白、α-突触核蛋白、转甲状腺蛋白、胰岛淀粉样多肽、心钠素以及新发现的含有表皮生长因子的纤维蛋白样胞外基质蛋白1。除脑内淀粉样变性外，大多数与年龄相关的淀粉样变性研究较少。事实上，鉴于我们社会的预期寿命越来越长，了解衰老是如何参与淀粉样蛋白纤维积累的过程以及淀粉样蛋白沉积对衰老身体的影响是极其重要的。本文就淀粉样前体蛋白的性质、淀粉样变性的患病率、临床表现和发病机制，以及脑外年龄相关淀粉样变性的最新研究进展作一综述。
Inside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer’s and Parkinson’s diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid β protein, α-synuclein, transthyretin, islet amyloid polypeptide, atrial natriuretic factor, and the newly discovered epidermal growth factor-containing fibulin-like extracellular matrix protein 1. Except for intracerebral amyloidoses, most age-related amyloidoses have been little studied. Indeed, in view of the increasing life expectancy in our societies, understanding how aging is involved in the process of amyloid fibril accumulation and the effects of amyloid deposits on the aging body is extremely important. In this review, we summarize current knowledge about the nature of amyloid precursor proteins, the prevalence, clinical manifestations, and pathogenesis of amyloidosis, and recent advances in our understanding of age-related amyloidoses outside the brain.