Prediction of Appendicular Skeletal and Fat Mass in Children: Excellent Concordance of Dual-energy X-ray Absorptiometry and Magnetic Resonance Imaging
Prediction of Appendicular Skeletal and Fat Mass in Children: Excellent Concordance of Dual-energy X-ray Absorptiometry and Magnetic Resonance Imaging
复制标题
儿童四肢骨骼和脂肪量的预测：双能 X 射线吸收测定法和磁共振成像的出色一致性
DOI：
10.1515/jpem.2009.22.9.795
复制
发表时间：
2009
影响因子：
1.4
通讯作者：
M. Thompson
中科院分区：
文献类型：
--
作者：
Pascale Bridge;N. Pocock;Tuan Nguyen;C. Munns;C. Cowell;M. Thompson
BACKGROUND
Body composition studies in children have great potential to help understand the aetiology and evolution of acute and chronic. diseases.
AIM
To validate appendicular lean soft tissue mass (LSTM) and fat mass (FM) measured using dual energy X-ray absorptiometry (DXA), with magnetic resonance imaging (MRI) as the reference standard, in healthy peri-pubertal adolescents.
DESIGN
Peri-pubertal Caucasian children (n = 74) aged 11-14 years were evaluated. DXA LSTM and FM of the mid third femur were measured and skeletal muscle mass (SM) and FM of the same region were measured on the same day by MRI.
RESULTS
There was a strong correlation between MRI SM and DXA LSTM (r2 = 0.98, index of concordance [C] = 0.91). DXA estimation of LSTM exceeded MRI SM by a mean of 189 g, from 6-371 g (p < 0.0001). The discordance between DXA and MRI significantly increased with the absolute value (r = 0.27; p = 0.024). FM was highly correlated (r = 0.98) with a high index of concordance (C = 0.97).
CONCLUSION
This study validates the use of DXA in LSTM measurement in children, confirming its potential in clinical and research roles in paediatric diseases affecting and related to body composition.
