Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.
Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.
复制标题
通过荧光原位杂交将编码 melanocortin-2（促肾上腺皮质激素）和 melanocortin-3 受体的基因定位于染色体 18p11.2 和 20q13.2-q13.3。
DOI：
10.1006/geno.1993.1448
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发表时间：
1993
期刊：
影响因子：
4.4
通讯作者：
Yamada,T
中科院分区：
文献类型：
--
作者：
Gantz,I;Tashiro,T;Barcroft,C;Konda,Y;Shimoto,Y;Miwa,H;Glover,T;Munzert,G;Yamada,T
促肾上腺皮质激素（ACTH）和[α]-、[β]-和[γ]-促黑素细胞激素（MSH）是丙黑皮素翻译后加工的产物。这些化合物统称为黑皮质素（MC）。除了它们对肾上腺皮质（ACTH）和黑素细胞（[α]-MSH）的调节的既定作用外，黑皮质素还涉及广泛的生理事件。黑皮质素通过属于七种跨膜G蛋白连接受体超家族的细胞膜受体介导其作用。使用聚合酶链反应技术，引物基于7个跨膜G蛋白连接受体家族的保守区域，作者最近分离出了该受体组的一个[开放引号]孤儿[关闭引号]亚家族。在过去的一年中，这些受体中的两种被鉴定为[alpha]-MSH（MC 1）和ACTH（MC 2）的特异性。他们最近描述了第三种黑皮质素受体（MC 3），似乎可以识别黑皮质素的核心七肽序列，具有相同的效力和功效，并确定其存在于大脑，胎盘和肠道中。使用FISH技术，他们将ACTH和黑皮质素-3受体分别定位于染色体位点18p11.2和20q12.3-q13.2。参考文献19篇，1图
Adrenocorticotropic hormone (ACTH) and [alpha]-, [beta]-, and [gamma]-melanocyte-stimulating hormone (MSH) are products of propiomelanocortin post-translational processing. These compounds are collectively labeled as melanocortins (MC). Aside from their established effects on the regulation of the adrenal cortex (ACTH) and melanocytes ([alpha]-MSH), the melanocortins have been implicated in a broad array of physiological events. Melanocortins mediate their effects through cell membrane receptors belonging to the superfamily of seven transmembrane G-protein-linked receptors. Using the technique of polymerase chain reaction with primers based on conserved areas of the seven transmembrane G-protein-linked receptor family, the authors recently isolated an [open quotes]orphan[close quotes] subfamily of this receptor group. Within the past year, two of these receptors were identified as specific for [alpha]-MSH (MC1) and ACTH (MC2). They have recently described a third melanocortin receptor (MC3) that appears to recognize the core heptapeptide sequence of melanocortins with equal potency and efficacy and identified its presence in the brain, placenta, and gut. Using the FISH technique, they localized the ACTH and the melanocortin-3 receptors to chromosome loci 18p11.2 and 20q12.3-q13.2, respectively. 19 refs., 1 fig.