Epigenetic dynamics during preimplantation development.
Epigenetic dynamics during preimplantation development.
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植入前发育过程中的表观遗传动力学。
DOI：
10.1530/rep-15-0180
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Mager J
中科院分区：
文献类型：
--
作者：
Marcho C;Cui W;Mager J
哺乳动物的成功发育需要单细胞受精卵的后代分化成不同的细胞类型，即使它们含有相同的遗传物质。植入前动力学首先由重编程单倍体亲本表观基因组以达到全能状态的必要性驱动。这一过程需要在受精后不久大量擦除表观遗传标记。在受精卵形成后的短短几天内，表观遗传程序建立起来，对第一谱系决定和分化至关重要。在这里，我们回顾了目前的理解，DNA甲基化和组蛋白修饰的动态负责这些早期变化在哺乳动物植入前发育。特别是，我们强调了通过下一代测序技术将人类胚胎与其他模型进行比较所获得的见解，以及最近发现的在植入前发挥作用的主动DNA去甲基化机制。
Successful mammalian development requires descendants of single-cell zygotes to differentiate into diverse cell types even though they contain the same genetic material. Preimplantation dynamics are first driven by the necessity of reprogramming haploid parental epigenomes to reach a totipotent state. This process requires extensive erasure of epigenetic marks shortly after fertilization. During the few short days after formation of the zygote, epigenetic programs are established and are essential for the first lineage decisions and differentiation. Here we review the current understanding of DNA methylation and histone modification dynamics responsible for these early changes during mammalian preimplantation development. In particular we highlight insights that have been gained through next generation sequencing technologies comparing human embryos to other models as well as the recent discoveries of active DNA demethylation mechanisms at play during preimplantation.