Relationship between gyrification and functional connectivity of the prefrontal cortex in subjects at high genetic risk of schizophrenia.
Relationship between gyrification and functional connectivity of the prefrontal cortex in subjects at high genetic risk of schizophrenia.
复制标题
DOI：
10.2174/138161212799316235
复制
发表时间：
2012-01
影响因子：
3.1
通讯作者：
M. Dauvermann;P. Mukherjee;William T Moorhead;A. Stanfield;P. Fusar-Poli;S. Lawrie;H. Whalley
中科院分区：
文献类型：
--
作者：
M. Dauvermann;P. Mukherjee;William T Moorhead;A. Stanfield;P. Fusar-Poli;S. Lawrie;H. Whalley
据报道，精神分裂症患者的皮质折叠（“回旋”）和连接性测量均受到干扰。还有报道称，前额叶回旋的增加可能预示着有该疾病家族风险的个体随后患病。因此，此类措施具有重要的潜在临床意义。然而，皮层形态与潜在连接之间关系的本质尚不清楚。在当前的研究中，我们试图探索一群患有该疾病的高遗传风险个体的回转测量和功能连接之间的关系。理论背景基于这样的假设：前额皮质的回旋指数（GI）增加可能反映了短程区域连通性的增加。该队列由 68 名未受影响的年轻精神分裂症患者亲属和 21 名健康对照者组成。使用自动环化指数法（A-GI）评估皮质折叠。参与者在扫描仪中执行 Hayling 句子完成范式，并使用基于相关性的方法评估功能连接的测量。在高风险受试者中，前额胃肠道和前额外侧-内侧连接之间发现显着正相关，而前额GI和前额丘脑连接之间发现负相关。这些关联表明，描述大脑表面形态特征的测量与高风险受试者的潜在功能连接的测量相关。高风险人群的相关性比对照组更明显。因此，我们认为我们之前发现的前额叶回旋增加可能与局部短程前额连接性增加和远程连接性减少有关。
Measures of cortical folding ('gyrification') and connectivity are both reported to be disrupted in schizophrenia. There are also reports that increases in prefrontal gyrification may be predictive of subsequent illness in individuals at familial risk of the disorder. Such measures therefore have important potential clinical relevance. The nature of the relationship between cortical morphology and underlying connectivity is however unclear. In the current study we sought to explore the relationship between measures of gyrification and functional connectivity in a cohort of individuals at high genetic risk for the disorder. The theoretical background is based on the hypothesis that increased gyrification index (GI) in the prefrontal cortex may reflect increased short range regional connectivity. The cohort comprised 68 young unaffected relatives of schizophrenia patients and 21 healthy controls. Cortical folding was assessed using an automated Gyrification Index method (A-GI). Participants performed the Hayling sentence completion paradigm in the scanner and measures of functional connectivity were assessed using a correlation based approach. In the high risk subjects significant positive associations were found between prefrontal GI and prefrontal lateral-medial connectivity, while a negative correlation was found between prefrontal GI and prefrontal-thalamic connectivity. These associations indicate that measures describing morphological features of the brain surface relate to measures of underlying functional connectivity in the high risk subjects. Correlations in high risk people were more pronounced than in control subjects. We suggest our previous finding of increased prefrontal gyrification may therefore relate to increased local short range prefrontal connectivity and reduced long range connectivity.