The LuxR Family Quorum-Sensing Activator MrtR Requires Its Cognate Autoinducer for Dimerization and Activation but Not for Protein Folding
The LuxR Family Quorum-Sensing Activator MrtR Requires Its Cognate Autoinducer for Dimerization and Activation but Not for Protein Folding
复制标题
LuxR 系列群体感应激活剂 MrtR 需要其同源自诱导剂进行二聚化和激活，但不需要蛋白质折叠
DOI：
10.1128/jb.01247-08
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Zhu, Jun
中科院分区：
文献类型：
--
作者：
Yang, Menghua;Giel, Jennifer L.;Zhu, Jun
摘要 MrtR 是天山中索尔根瘤菌中的 LuxR 同源物，对于共生至关重要。我们发现MrtR需要其同源N-酰基高丝氨酸内酯来形成二聚体、结合到单个DNA位点并激活下游启动子。然而，MrtR 能够独立于其配体进行折叠。
ABSTRACT MrtR, a LuxR homolog in Mesorhizobium tianshanense, is important for symbiosis. We found that MrtR requires its cognate N-acylhomoserine lactone for forming dimers, binding to a single DNA site and activating the downstream promoter. However, MrtR is able to fold independently of its ligand.