Characterization of Urinary Stone Composition by Use of Third-Generation Dual-Source Dual-Energy CT With Increased Spectral Separation.
Characterization of Urinary Stone Composition by Use of Third-Generation Dual-Source Dual-Energy CT With Increased Spectral Separation.
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DOI：
10.2214/ajr.15.14348
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
McCollough CH
中科院分区：
文献类型：
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作者：
Duan X;Li Z;Yu L;Leng S;Halaweish AF;Fletcher JG;McCollough CH
本体模研究的目的是确定第三代双源CT扫描仪在区分泌尿系结石成分方面的实用性，该扫描仪具有增加的双能谱分离。在35-，40-，45-，和50-cm宽的拟人模型中，使用第三代双源扫描仪（系统A），150 kV的高能量束加0.6 mm锡过滤（Sn），对87例人类泌尿系结石进行扫描。在70、80、90和100 kV下采集低能数据。使用第二代双源扫描仪（系统B）在140 kV加0.4 mm Sn下采集高能量图像数据，在80或100 kV下采集低能量图像数据。体积CT剂量指数与给定的体模尺寸相匹配。计算CT比值，并在ROC分析中用于区分尿酸结石和非尿酸结石以及草酸盐结石和磷灰石结石。尿酸结石与非尿酸结石的ROC曲线下面积（AUC）在大结石中增加。例如，对于45 cm宽体模的成像，系统A在100和150 kV Sn低能量和高能量组合下的AUC为0.99，而系统B在100和140 kV Sn组合下的AUC为0.86。在每个体模尺寸和所有能量组合下，系统A的草酸盐结石与磷灰石结石的AUC值高于系统B的任何能量组合。与使用第二代双源CT相比，在100和150 kV Sn的能量组合下使用第三代双源CT改善了各种体模尺寸的泌尿系结石分类，并提高了区分草酸盐结石和磷灰石结石的能力。
The purpose of this phantom study was to determine the utility of a third-generation dual-source CT scanner with increased dual-energy spectral separation in differentiating urinary stone composition. Eighty-seven urinary stones from humans were scanned in 35-, 40-, 45-, and 50-cm wide anthropomorphic phantoms with a third-generation dual-source scanner (system A) with a high-energy beam of 150 kV plus 0.6-mm tin filtration (Sn). The low-energy data were acquired at 70, 80, 90, and 100 kV. A second-generation dual-source scanner (system B) was used to acquire data at 140 kV plus 0.4-mm Sn for the high-energy and 80 or 100 kV for the low-energy images. Volume CT dose index was matched for a given phantom size. CT number ratios were calculated and used to differentiate uric acid from non–uric acid stones and oxalate from apatite stones in an ROC analysis. The area under the curve (AUC) of the ROC curve for uric acid versus non–uric acid stones increased for large phantoms. For example, for imaging of the 45-cm wide phantom with system A at the 100- and 150-kV Sn low- and high-energy combination, the AUC was 0.99, whereas for system B at the 100- and 140-kV Sn combination, the AUC was 0.86. At each phantom size and for all energy combinations, the AUC values for oxalate versus apatite stones were higher for system A than they were for any energy combination for system B. Compared with use of second-generation dual-source CT, use of third-generation dual-source CT at the energy combination of 100 and 150 kV Sn improved classification of urinary stones across a wide range of phantom sizes and increased the ability to differentiate oxalate from apatite stones.