Knockout mutagenesis of the kpsE gene of Campylobacter jejuni 81116 and its involvement in bacterium-host interactions
Knockout mutagenesis of the kpsE gene of Campylobacter jejuni 81116 and its involvement in bacterium-host interactions
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DOI：
10.1111/j.1574-695x.2006.00182.x
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发表时间：
2007-02-01
影响因子：
--
通讯作者：
Fry, Benjamin N.
中科院分区：
文献类型：
--
作者：
Bachtiar, Boy M.;Coloe, Peter J.;Fry, Benjamin N.
空肠弯曲杆菌是细菌性肠炎的常见病因。表面荚膜多糖对这种细菌在环境中生存很重要，但对它们在细菌-宿主相互作用中的作用知之甚少。本研究表明，空肠梭菌荚膜多糖对人胚胎上皮细胞的粘附和侵袭具有重要作用。然而，荚膜多糖在鸡肠道的定植中没有显著的作用。
Campylobacter jejuni is a common cause of bacterial enteritis. The surface capsular polysaccharides are important for this bacterium to survive in the environment, but little is known about their involvement in bacterium-host interactions. This study showed that the C. jejuni capsular polysaccharides play an important role in adherence to and invasion of human embryonic epithelial cells. However, no significant role of capsular polysaccharides was shown in colonization of the chicken gut.