REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.
REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.
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活性氧与结直肠癌
DOI：
10.1007/s11888-013-0190-5
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发表时间：
2013-12
影响因子：
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通讯作者：
Safe, Stephen
中科院分区：
文献类型：
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作者：
Sreevalsan, Sandeep;Safe, Stephen
几种用于治疗结肠癌和其他癌症的药物诱导活性氧（ROS），这在其抗癌活性中起着重要作用。除了众所周知的ROS诱导剂的促凋亡作用外，这些化合物还降低特异性蛋白（Sp）转录因子Sp1、Sp3和Sp 4以及对癌细胞增殖、存活和转移重要的几种原癌Sp调节基因的表达。这些反应的机制涉及miR-27 a或miR-20 a（和旁系同源物）的ROS依赖性下调以及两种Sp阻遏物ZBTB 10和ZBTB 4的诱导。该途径显著有助于ROS诱导剂的抗癌活性，并且在开发用于癌症化疗的药物组合时应予以考虑。
Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS), and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 and several prooncogenic Sp-regulated genes important for cancer cell proliferation, survival, and metastasis. The mechanism of these responses involves ROS-dependent downregulation of miR-27a or miR-20a (and paralogs) and induction of two Sp repressors, ZBTB10 and ZBTB4, respectively. This pathway significantly contributes to the anticancer activity of ROS inducers and should be considered in the development of drug combinations for cancer chemotherapy.