Sustained high level of serum VEGF at convalescent stage contributes to the renal recovery after HTNV infection in patients with hemorrhagic fever with renal syndrome.
Sustained high level of serum VEGF at convalescent stage contributes to the renal recovery after HTNV infection in patients with hemorrhagic fever with renal syndrome.
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DOI：
10.1155/2012/812386
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发表时间：
2012
影响因子：
--
通讯作者：
Jin B
中科院分区：
文献类型：
--
作者：
Ma Y;Liu B;Yuan B;Wang J;Yu H;Zhang Y;Xu Z;Zhang Y;Yi J;Zhang C;Zhou X;Yang A;Zhuang R;Jin B
为探讨血管内皮生长因子（VEGF）在汉滩病毒（HTNV）感染后血管内皮细胞通透性增加中的作用，采用双抗体夹心ELISA法检测了HTNV感染者血清中VEGF的浓度。患者血清VEGF水平普遍升高至607.0（542.2-671.9）pg/mL，显著高于健康对照组（P < 0.001）。所有患者从发热至少尿期血清VEGF水平均迅速升高，血肌酐达到高峰，提示VEGF可能参与了肾高通透性的发病过程。恢复期血清VEGF水平与病情严重程度呈正相关。HFRS危重患者恢复期血清VEGF水平持续升高，提示VEGF可能有助于病毒清除后肾功能的恢复。总而言之，我们的结果表明，血管内皮生长因子可能参与HTNV感染后少尿期肾功能障碍的发病机制，但可能在恢复期作为恢复因子，帮助身体自我修复肾损伤。
To investigate the role of vascular endothelial growth factor (VEGF) in the increased permeability of vascular endothelial cells after Hantaan virus (HTNV) infection in humans, the concentration of VEGF in serum from HTNV infected patients was quantified with sandwich ELISA. Generally, the level of serum VEGF in patients was elevated to 607.0 (542.2–671.9) pg/mL, which was dramatically higher compared with healthy controls (P < 0.001). There was a rapid increase of the serum VEGF level in all patients from the fever onset to oliguric stage, at which the serum creatinine reached the peak level of the disease, indicating that VEGF may be involved in the pathogenesis of renal hyper-permeability. Moreover, the serum VEGF level at convalescent stage was positively correlated with the degree of the disease severity. The sustained high level of serum VEGF at convalescence was observed in critical HFRS patients, suggesting that VEGF would probably contribute to the renal recovery after the virus clearance. Taken together, our results suggested that the VEGF would be involved in the pathogenesis of renal dysfunction at the oliguric stage after HTNV infection, but may function as a recovery factor during the convalescence to help the body self-repair of the renal injury.