The presence of an aldehyde dehydrogenase inhibitor in animal diets and its effects on the experimental results in alcohol studies
The presence of an aldehyde dehydrogenase inhibitor in animal diets and its effects on the experimental results in alcohol studies
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动物饮食中乙醛脱氢酶抑制剂的存在及其对酒精研究实验结果的影响
DOI：
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发表时间：
1978
影响因子：
3.6
通讯作者：
N. Karlsson
中科院分区：
文献类型：
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作者：
O. Tottmar;H. Marchner;N. Karlsson
1. 研究了慢性乙醇给药对乙醇和乙醛代谢的影响。实验用商业饲料喂养大鼠，饲料中含有醛脱氢酶抑制剂氰酰胺钙（碳酰亚胺钙），作为饲料中煅烧骨粉部分的污染物。2. 在连续3个月给予150ml /l乙醇溶液并喂食含有煅烧骨粉的饲料的大鼠中，肝脏中低km乙醛脱氢酶的活性比喂食相同饲料的对照大鼠高2倍，乙醇消除率高26%，在乙醇消除期间血液中乙醛水平比喂食相同饲料的对照大鼠低2 - 3倍。3. 乙醇处理大鼠的实验结果与不含煅烧骨粉的对照组大鼠的实验结果相似。4. 体外和体内对三聚氰胺抑制乙醛代谢的实验表明，慢性乙醇摄入的明显影响实际上是由饮食中的三聚氰胺钙引起的。
1. The effects of chronic ethanol administration on the metabolism of ethanol and acetaldehyde were studied in rats fed on a commercial diet containing an aldehyde dehydrogenase inhibitor, calcium cyanamide (calcium carbimide), as a contaminant in the calcinated bone-meal fraction of the diet. 2. Rats given an ethanol solution (150 ml/l) for 3 months and fed on a diet containing calcinated bone meal showed two times higher activity of the low-Km acetaldehyde dehydrogenase in the liver, 26 % higher rate of ethanol elimination, and two to three times lower acetaldehyde levels in blood during ethanol elimination compared with control rats pair-fed on the same diet. 3. The results obtained from the ethanol-treated rats were similar to those obtained in experiments on control rats fed on diets not containing calcinated bone meal. 4. Experiments performed in vitro and in vivo on the inhibition of the acetaldehyde metabolism by cyanamide suggested that the apparent effects of chronic ethanol intake were really caused by calcium cyanamide in the diet.