Bench to bedside review of myositis autoantibodies.
Bench to bedside review of myositis autoantibodies.
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DOI：
10.1186/s12948-018-0084-9
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Parronchi P
中科院分区：
文献类型：
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作者：
Palterer B;Vitiello G;Carraresi A;Giudizi MG;Cammelli D;Parronchi P
特发性炎症性肌病是一种异质性的自身免疫性疾病，具有全身性。尽管已经发现了许多特异性自身抗体，但除抗jo -1抗体外，它们尚未被纳入2017年的分类标准，从而使临床-血清学差距持续存在。缺乏基于抗体谱的同质分组深深地影响了这些患者的诊断方法、治疗选择和预后分层。这篇综述旨在强调肌炎相关自身抗体的综合情况，从分子特征和生物学意义到靶抗原，从检测工具，特别关注HEp-2细胞的免疫荧光模式，到它们的相对患病率和种族多样性，从临床表现到预后。如果，一方面，有显著的文献存在，另一方面，数据是碎片化的，回顾性的，从小病例系列中收集的，因此它们不能充分支持诊所的决策过程（即治疗方法）。
Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. This review is intended to highlight the comprehensive scenario regarding myositis-related autoantibodies, from the molecular characterization and biological significance to target antigens, from the detection tools, with a special focus on immunofluorescence patterns on HEp-2 cells, to their relative prevalence and ethnic diversity, from the clinical presentation to prognosis. If, on the one hand, a notable body of literature is present, on the other data are fragmented, retrospectively based and collected from small case series, so that they do not sufficiently support the decision-making process (i.e. therapeutic approach) into the clinics.