Review: Hippocampal sclerosis in epilepsy: a neuropathology review.
Review: Hippocampal sclerosis in epilepsy: a neuropathology review.
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DOI：
10.1111/nan.12150
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发表时间：
2014-08
影响因子：
5
通讯作者：
Thom M
中科院分区：
文献类型：
--
作者：
Thom M
海马硬化（HS）是内侧颞叶癫痫（MTLE）以及其他癫痫综合征以及手术和尸检实践中遇到的常见病理。 2013 年国际抗癫痫联盟 (ILAE) 分类根据亚区神经元缺失和神经胶质增生的组织学模式将 HS 分为典型（1 型）和非典型（2 型和 3 型）组。此外，颗粒细胞重组和中间神经元群、神经肽纤维网络和苔藓纤维出芽的改变是与癫痫相关的 HS 的显着特征；它们可以作为有用的诊断辅助工具来区分热射病的其他原因，并强调海马癫痫发生的潜在机制。热射病的病因仍然难以捉摸，可能是多种因素造成的；讨论了热性惊厥、遗传易感性、炎症和神经发育因素的影响。热射病的尸检研究作为手术样本研究的补充，具有额外的优势，可以研究与热射病相关的更广泛的网络变化、癫痫对病理学和相关合并症的长期影响。热射病的病因、癫痫发生机制、网络改变以及对药物和手术治疗的反应等方面可能存在异质性。未来的神经病理学研究将有助于更好地认识和理解 HS 的这些临床和病理病因亚型。
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post-mortem practice. The 2013 International League Against Epilepsy (ILAE) classification segregates HS into typical (type 1) and atypical (type 2 and 3) groups, based on the histological patterns of subfield neuronal loss and gliosis. In addition, granule cell reorganization and alterations of interneuronal populations, neuropeptide fibre networks and mossy fibre sprouting are distinctive features of HS associated with epilepsies; they can be useful diagnostic aids to discriminate from other causes of HS, as well as highlighting potential mechanisms of hippocampal epileptogenesis. The cause of HS remains elusive and may be multifactorial; the contribution of febrile seizures, genetic susceptibility, inflammatory and neurodevelopmental factors are discussed. Post-mortem based research in HS, as an addition to studies on surgical samples, has the added advantage of enabling the study of the wider network changes associated with HS, the long-term effects of epilepsy on the pathology and associated comorbidities. It is likely that HS is heterogeneous in aspects of its cause, epileptogenetic mechanisms, network alterations and response to medical and surgical treatments. Future neuropathological studies will contribute to better recognition and understanding of these clinical and patho-aetiological subtypes of HS.
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影响因子：
6.1
作者：
Aronica, E.;Boer, K.;Jeromin, A.
通讯作者：
Jeromin, A.
影响因子：
11.2
作者：
Baulac, M;De Grissac, N;Berger, B
通讯作者：
Berger, B
影响因子：
5
作者：
Bandopadhyay R;Liu JY;Sisodiya SM;Thom M
通讯作者：
Thom M
影响因子：
9.9
作者：
Bien, C. G.;Urbach, H.;Elger, C. E.
通讯作者：
Elger, C. E.
影响因子：
2.6
作者：
Bertram, Edward H.
通讯作者：
Bertram, Edward H.