Treatment of Central Sleep Apnea in US Veterans
Treatment of Central Sleep Apnea in US Veterans
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DOI：
10.5664/jcsm.2156
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Badr, M. Safwan
中科院分区：
文献类型：
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作者：
Chowdhuri, Susmita;Ghabsha, Ahmed;Badr, M. Safwan
背景：中枢性睡眠呼吸暂停(CSA)的治疗尚无标准疗法。无论是正压治疗(PAP)还是补充氧气(O-2)均可通过降低呼吸机的化学反应性来稳定CsA患者的呼吸。此外，阿片类药物使用的增加和美国退伍军人合并疾病的存在，使得有必要研究治疗CSA的替代滴定方案。该研究的目的是报告单独或与氧气联合使用PAP滴定治疗与不同并发症和阿片类药物使用相关的环孢素A的有效性。方法：这是在退伍军人管理局睡眠障碍中心进行的为期3年的回顾图表。结果：162例CsA患者均确诊为CsA，分别采用CPAP、CPAP+O2和BPAP+O2三种方案进行逐步滴定。该方案对消除CSA(CAI)是有效的
Background: There are no standard therapies for the management of central sleep apnea (CSA). Either positive pressure therapy (PAP) or supplemental oxygen (O-2) may stabilize respiration in CSA by reducing ventilatory chemoresponsiveness. Additionally, increasing opioid use and the presence of comorbid conditions in US veterans necessitates investigations into alternative titration protocols to treat CSA. The goal was to report on the effectiveness of titration with PAP, used alone or in conjunction with O-2, for the management of CSA associated with varying comorbidities and opioid use.Methods: This was a retrospective chart review over 3 years, performed at a VA sleep disorders center. The effects of CPAP, CPAP+O-2, and BPAP+O-2, used in a step-wise titration protocol, on consecutive patients diagnosed with CSA were studied.Results: CSA was diagnosed in 162 patients. The protocol was effective in eliminating CSA (CAI