Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
复制标题
DOI：
10.1016/s0091-3057(01)00527-5
复制
发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Hatsukami, DK
中科院分区：
文献类型：
--
作者：
Sofuoglu, M;Babb, DA;Hatsukami, DK
本研究的目的是（1）检查在卵泡早期内源性雌二醇和孕酮水平较低时给予女性孕酮的可行性，以及（2）调查口服孕酮治疗对女性吸烟者吸烟行为的影响。12名受试者在月经开始后3-9天内进行了两次实验。在每个实验阶段，受试者口服单次200 mg剂量的孕酮或安慰剂。两个半小时：在药物治疗后，评估受试者对两口香烟的主观反应，然后开始自我给药期，其中他们可以选择将他们的代币交换为两口香烟，间隔15分钟。受试者在第一次和第二次治疗前雌二醇和孕酮水平较低。血浆孕酮水平在孕酮治疗后2小时达到峰值。预后治疗减弱了吸烟的渴望和主观影响。在孕酮治疗下，吸烟行为有减少的趋势。这些初步结果表明，月经周期的早期卵泡期可能是一个有用的间隔，以调查外源性孕酮的影响，女性吸烟者。孕酮对尼古丁依赖的影响有待进一步研究。(C)2001 Elsevier Science Inc. All rights reserved.
The goals of this study were (1) to examine the feasibility of administering progesterone to women during the early follicular phase when the endogenous estradiol and progesterone levels are low, and (2) to investigate the effects of oral progesterone treatment on smoking behavior in female smokers. Twelve subjects had two experimental sessions, within 3-9 days after the beginning of their menses. In each experimental session, subjects received a single 200-mg dose of progesterone or placebo, orally. Two and a half hours: after the medication treatment, subjects were assessed for subjective response to two puffs of a cigarette and then started the self-administration period in which they had the option to exchange their token for two puffs of cigarette, 15 min apart. Subjects had low levels of estradiol and progesterone before the first and second sessions. Plasma progesterone levels peaked in 2 h following progesterone treatment. Progesterone treatment attenuated the craving for and subjective effects from smoking. Under progesterone treatment, there was a trend for decreased smoking behavior. These preliminary results suggest that the early follicular phase of the menstrual cycle may be a useful interval to investigate the effects of exogenous progesterone in female smokers. The effects of progesterone on nicotine dependence need to be studied further. (C) 2001 Elsevier Science Inc. All rights reserved.