Abnormal topological organization of the white matter network in Mandarin speakers with congenital amusia.
Abnormal topological organization of the white matter network in Mandarin speakers with congenital amusia.
复制标题
先天性失乐症普通话使用者白质网络拓扑结构异常
DOI：
10.1038/srep26505
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发表时间：
2016-05-23
影响因子：
4.6
通讯作者：
Nan Y
中科院分区：
文献类型：
--
作者：
Zhao Y;Chen X;Zhong S;Cui Z;Gong G;Dong Q;Nan Y
先天性健忘症是一种神经遗传性疾病，主要影响音高的加工。脑成像证据表明，它与额颞区的结构和功能异常连接有关。然而，对失语症背后的解剖学拓扑结构的整体理解仍然缺乏。在这里，我们使用概率扩散张量成像术和图论来检查31例说普通话的娱乐组和24名年龄和智商匹配的对照组的全脑白质结构连通性。AMUSICS显示，与对照组相比，全球连接性显著降低，集群系数(CP)异常降低，归一化最短路径长度(λ)增加。此外，与对照组相比，AMUSICS患者右侧顶下小叶的结节强度增强。归一化最短路径长度(λ)的增加与词汇声调知觉的不敏感度之间的显著相关表明，词汇声调缺陷的存在与娱乐游戏中全球网络效率的进一步下降有关。我们的研究首次揭示了娱乐游戏中全球连接效率的降低以及由于共存的词汇声调缺陷而导致全球连接成本的增加。综上所述，这些结果为先天性健忘症的解剖基础提供了一个整体的视角。
Congenital amusia is a neurogenetic disorder that mainly affects the processing of musical pitch. Brain imaging evidence indicates that it is associated with abnormal structural and functional connections in the fronto-temporal region. However, a holistic understanding of the anatomical topology underlying amusia is still lacking. Here, we used probabilistic diffusion tensor imaging tractography and graph theory to examine whole brain white matter structural connectivity in 31 Mandarin-speaking amusics and 24 age- and IQ-matched controls. Amusics showed significantly reduced global connectivity, as indicated by the abnormally decreased clustering coefficient (Cp) and increased normalized shortest path length (λ) compared to the controls. Moreover, amusics exhibited enhanced nodal strength in the right inferior parietal lobule relative to controls. The co-existence of the lexical tone deficits was associated with even more deteriorated global network efficiency in amusics, as suggested by the significant correlation between the increments in normalized shortest path length (λ) and the insensitivity in lexical tone perception. Our study is the first to reveal reduced global connectivity efficiency in amusics as well as an increase in the global connectivity cost due to the co-existed lexical tone deficits. Taken together these results provide a holistic perspective on the anatomical substrates underlying congenital amusia.