Raman spectroscopy for noninvasive glucose measurements - art. no. 031114
Raman spectroscopy for noninvasive glucose measurements - art. no. 031114
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DOI：
10.1117/1.1920212
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发表时间：
2005-05-01
影响因子：
3.5
通讯作者：
Feld, MS
中科院分区：
文献类型：
--
作者：
Enejder, AMK;Scecina, TG;Feld, MS
我们报告了首次成功使用拉曼光谱对血液分析物进行定量、无创（“经皮”）测量的研究，以葡萄糖为例。作为对拉曼光谱经皮测量葡萄糖能力的初步评估，我们研究了17名健康人，他们的血糖水平在2-3小时内升高，使用标准葡萄糖耐量试验方案。在测试过程中，经皮收集461个拉曼光谱，并通过标准毛细管血液分析提供葡萄糖参考值。根据每个受试者的数据创建偏最小二乘校准，并使用留一交叉验证进行验证。每位受试者的平均绝对误差为7.8% +/- 61.8%（平均+/- std）， R-2值为0.83 +/- 0.10。通过对校正回归向量的分析，我们提供了葡萄糖光谱是校正的重要组成部分的光谱证据。(c) 2005年光学仪器工程师学会。
We report the first successful study of the use of Raman spectroscopy for quantitative, noninvasive ("transcutaneous") measurement of blood analytes, using glucose as an example. As an initial evaluation of the ability of Raman spectroscopy to measure glucose transcutaneously, we studied 17 healthy human subjects whose blood glucose levels were elevated over a period of 2-3 h using a standard glucose tolerance test protocol. During the test, 461 Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation. The mean absolute errors for each subject were 7.8% +/- 61.8% (mean +/- std) with R-2 values of 0.83 +/- 0.10. We provide spectral evidence that the glucose spectrum is an important part of the calibrations by analysis of the calibration regression vectors. (c) 2005 Society of Photo-Optical Instrumentation Engineers.