Axonal transcription factors signal retrogradely in lesioned peripheral nerve
Axonal transcription factors signal retrogradely in lesioned peripheral nerve
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DOI：
10.1038/emboj.2011.494
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发表时间：
2012-03-21
期刊：
影响因子：
11.4
通讯作者：
Fainzilber, Mike
中科院分区：
文献类型：
--
作者：
Ben-Yaakov, Keren;Dagan, Shachar Y.;Fainzilber, Mike
逆行轴突损伤信号刺激受损外周神经元的胞体反应。提示转录因子(TF)可能直接参与轴突损伤信号的传递。在这里，我们发现在轴突中发现了多个TF，并与损伤神经的轴浆中的动力蛋白有关。对一个TF家族的生化和功能验证表明，轴突STAT3在损伤后被局部翻译和激活，并与动力蛋白和输入素α5一起逆行运输，调节损伤后外周感觉神经元的存活。因此，轴突损伤部位的TF逆行运输在轴突和核之间提供了直接的联系。EMBO期刊(2012)31,1350-1363。DOI：10.1038/实施例.2011.494；2012年1月13日在线发布
Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha 5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus. The EMBO Journal (2012) 31, 1350-1363. doi: 10.1038/emboj. 2011.494; Published online 13 January 2012