Determination of Regional Cerebral Blood Flow by Inhalation of 133‐Xenon
Determination of Regional Cerebral Blood Flow by Inhalation of 133‐Xenon
复制标题
吸入 133-氙测定局部脑血流量
DOI：
10.1161/01.res.20.1.124
复制
发表时间：
1967
影响因子：
20.1
通讯作者：
H. Wang
中科院分区：
文献类型：
--
作者：
W. Obrist;H. Thompson;Herschel King;H. Wang
用于估计区域脑血流量的方法描述，其中示踪剂量的133被吸入2分钟，并在接下来的45至60分钟内监测颅外。一个三室模型用于分析所得到的清除率曲线提供了单独的血流“灰色”和“白色”的问题，加上一个衰减常数缓慢的第三个组成部分，认为是来自脑外组织。该分析包括基于呼气或动脉血的放射性同位素浓度对所有三种组分的再循环进行校正。从分析结果进行了比较，通过更传统的二室方法，使用15个健康的年轻男性的数据。而三室法产生的测量值与通过已建立的技术获得的测量值（平均CBF = 54.7 ml/100 g/min）相当，二室分析得到的值始终较低（平均CBF = 30.2）。基于呼气和动脉采样的结果比较表明，呼气末空气是动脉血的合理替代品。虽然133氚吸入法在技术上比其他方法更简单，创伤更小，但由于存在明显的再循环和脑外污染，需要对数据进行复杂的分析处理。
A method for estimating regional cerebral blood flow is described in which tracer amounts of 133Xe are inhaled for 2 min and monitored extracranially over the next 45 to 60 min. A three-compartment model used to analyze the resulting clearance curves provided separate blood flows for “gray” and “white” matter, plus a decay constant for a slow third component, believed to arise from extracerebral tissue. The analysis included a correction for recirculation of all three components, based on radioisotope concentration of the expired air or arterial blood. Results from the analysis were compared with those obtained by the more traditional two-compartment approach, using data from 15 healthy young males. Whereas the three-compartment method yielded measurements comparable with those obtained by established techniques (average CBF = 54.7 ml/100 g/min), the two-compartment analysis gave consistently lower values (average CBF = 30.2). Comparison of results based on expired air and arterial sampling suggested that end-expiratory air is a reasonable substitute for arterial blood. Although the 133Xe inhalation method is technically simpler and less traumatic than other methods, complex analytic treatment of the data is necessitated by the presence of appreciable recirculation and extracerebral contamination.