Menstrual-linked asthma
Menstrual-linked asthma
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DOI：
10.3109/02770909709055398
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发表时间：
1997-01-01
影响因子：
1.9
通讯作者：
Shah, A
中科院分区：
文献类型：
--
作者：
Agarwal, AK;Shah, A
本研究旨在确定印度100例连续育龄女性哮喘患者的月经相关哮喘（MLA）发生率。患者被要求回答一份关于哮喘和月经周期之间关系的问卷。23例患者主观感觉哮喘症状恶化与月经周期有关。两组均有10例患者被要求连续2个月经周期记录每日呼气流量峰值（PEFR）日记。MLA患者的平均总病程明显长于无周期性加重的患者。咳嗽和呼吸困难也比疾病严重得多。这些患者更频繁的急诊室就诊和住院治疗证明了这一点。经期相关哮喘恶化在经前一周最为常见（17例）。在这17例患者中，有8例在月经期间也持续发生这种现象。有趣的是，1例患者在月经结束2天后哮喘恶化。这样的观察结果还有待记录。14例患者几乎每个周期症状加重，3例仅与特定季节有关。16名患者在经前期和/或经期几周经常需要额外的药物治疗。经前综合征的严重程度与MLA之间也存在显著关联。2个周期的平均PEFR值显示，与月经中期周相比，MLA患者经前期和月经周的早晨和晚上的PEFR值显着下降。这种下降在经前一周最大。在没有月经加重症状的哮喘患者中没有观察到这种下降。在印度大约四分之一的女性哮喘患者中检测到MLA，它似乎代表了一种更严重的疾病形式。该研究还证明MLA与气道阻力增加有关，而不仅仅是由于经前或月经周期间症状的增加。
This study was conducted to determine the occurrence of menstrual-linked asthma (MLA) in India in 100 consecutive female asthmatics in the reproductive age group. The patients were required to respond to a questionnaire concerning the relationship between their asthma and the menstrual cycle. Twenty-three patients had subjective perception of deterioration in symptoms of asthma in relation to the menstrual cycle. Ten patients from both groups were also required to maintain a daily peak expiratory flow rate (PEFR) diary for 2 consecutive menstrual cycles. The mean total duration of illness in patients with MLA was significantly longer than in patients without cyclic exacerbation. Cough and breathlessness were also significantly more severe as was the disease. This was evidenced by the more frequent emergency room visits and hospitalizations in these patients. Menstrual-linked worsening of asthma was most common in the premenstrual week (17 patients). In 8 of these 17 patients, this phenomenon continued to occur during the menstrual week also. Interestingly, 1 patient complained of deterioration of asthma 2 days after menstruation was over. Such an observation is yet to be recorded. Fourteen patients reported an increase in symptoms with almost every cycle while 3 had worsening related to specific season only. Sixteen patients often required extra medication during the premenstrual and/or menstrual weeks. A significant association was also observed between severity of premenstrual syndrome and MLA. The mean PEFR values over 2 cycles revealed a significant fall in the morning as well as evening values in the premenstrual and menstrual weeks as compared to the midcycle week in patients with MLA. This fall was maximal in the premenstrual week. Such a fall was not observed in asthmatics without menstrual exacerbation of symptoms. MLA was detected in about a fourth of the female asthmatics in India and it appears to represent a more severe form of the disease. This study also documented that MLA was associated with an increase in airway resistance and was not simply due to an increased perception of symptoms during the premenstrual or menstrual weeks.