Synthesis of calixarene-cyclodextrin coupling products
Synthesis of calixarene-cyclodextrin coupling products
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DOI：
10.1016/j.tet.2006.09.089
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发表时间：
2006-12-18
期刊：
影响因子：
2.1
通讯作者：
Mauclaire, L.
中科院分区：
文献类型：
--
作者：
Hocquelet, C.;Blu, J.;Mauclaire, L.
使用N，N '-琥珀酰二酰胺接头实现了两个或四个单-6-氨基β-环糊精（氨基-CD）单元（未保护的或全甲基化的羟基）与二异丙氧基杯[4]芳烃冠-6（CAL）的偶联。在两个系列中的所得分子的特征在于与质谱和NMR光谱的帮助。与羟基化CD系列或我们以前的研究相比，全甲基化糖系列的所有偶联产物的产率都有所提高。与二取代CAL偶联的两个β-环糊精（β-CD）残基从冠醚的同一侧定向。(c)2006爱思唯尔有限公司保留所有权利。
The coupling of two or four mono-6-amino beta-cyclodextrin (amino-CD) units, (unprotected or permethylated hydroxyls), to diisopropoxycalix[4]arene crown-6 (CAL) was realised using the N,N'-succinyldiamide linker. The resulting molecules in two series were characterised with the help of mass and NMR spectroscopies. The yields of all coupling products were improved for permethylated sugar series compared to the hydroxylated CD series or to our previous studies. The two beta-cyclodextrin (beta-CD) residues coupled to disubstituted CAL were orientated from the same side of the crown ether. (c) 2006 Elsevier Ltd. All rights reserved.