Gut Microbiota and Autism: Key Concepts and Findings
Gut Microbiota and Autism: Key Concepts and Findings
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DOI：
10.1007/s10803-016-2960-9
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发表时间：
2017-02-01
影响因子：
3.9
通讯作者：
Walkup, John T.
中科院分区：
文献类型：
--
作者：
Ding, Helen T.;Taur, Ying;Walkup, John T.
越来越多的证据将肠道微生物群与自闭症谱系障碍 (ASD) 联系起来。研究表明，自闭症谱系障碍儿童和对照组儿童的肠道细菌组成存在差异。某些肠道细菌被发现大量存在，可能与 ASD 的发病机制有关；包括梭菌属和沙氏菌属的成员。来自动物模型的证据表明，肠道中的某些微生物变化可能会产生与自闭症临床表现一致的变化，其机制包括毒素产生、发酵过程/产物异常以及免疫和代谢异常。在本文中，我们回顾了肠道细菌与 ASD 之间关系的研究，并讨论了可能涉及的细菌种类和提出的机制。
There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.