Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease.
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease.
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DOI：
10.1186/s41231-020-00073-y
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发表时间：
2020
影响因子：
--
通讯作者：
Mandal SM
中科院分区：
文献类型：
--
作者：
Paria K;Paul D;Chowdhury T;Pyne S;Chakraborty R;Mandal SM
自基督诞生以来，在这2019年里，地球上的人从未经历过任何非细胞原生生物的生存挑战，而不是SARS-CoV-2。尚未批准任何特定药物。宿主免疫是预防和/或降低感染率和死亡率的唯一选择。在这里，提出了一种黑色素介导的宿主免疫的新机制，在COVID-19的医疗保健管理中具有潜在的生物技术前景。已知维生素D可提高黑色素合成的速率;并且这可同时调节弗林蛋白酶表达的表达。计算机模拟分析表明，黑色素的中间体能够与弗林蛋白酶的活性位点强烈结合。另一方面，弗林蛋白酶的表达通过1-α-羟化酶（CYP 27 B1）负调控，该酶属于维生素D途径并控制细胞钙水平。在这里，我们设想了生物黑色素的可用性，并阐明了生物医学潜力。因此，我们提出了一种可能的协同应用的黑色素和酶CYP 27 B1（调节维生素D的生物合成）作为一种新的策略，以防止病毒进入通过弗林蛋白酶的失活，并帮助提高我们的免疫力在细胞和体液水平。
Since the birth of Christ, in these 2019 years, the man on earth has never experienced a survival challenge from any acellular protist compared to SARS-CoV-2. No specific drugs yet been approved. The host immunity is the only alternative to prevent and or reduce the infection and mortality rate as well. Here, a novel mechanism of melanin mediated host immunity is proposed having potent biotechnological prospects in health care management of COVID-19. Vitamin D is known to enhance the rate of melanin synthesis; and this may concurrently regulate the expression of furin expression. In silico analyses have revealed that the intermediates of melanin are capable of binding strongly with the active site of furin protease. On the other hand, furin expression is negatively regulated via 1-α-hydroxylase (CYP27B1), that belongs to vitamin-D pathway and controls cellular calcium levels. Here, we have envisaged the availability of biological melanin and elucidated the bio-medical potential. Thus, we propose a possible synergistic application of melanin and the enzyme CYP27B1 (regulates vitamin D biosynthesis) as a novel strategy to prevent viral entry through the inactivation of furin protease and aid in boosting our immunity at the cellular and humoral levels.